Success by design

With new plastics and processing techniques always becoming available, the design challenge becomes easier, even when taking today s solid-waste problem into account. Today s plastics and processes allow designers to incorporate and interrelate all the aspects of success. In products such as electronics, medical devices, transportation controls, and many others where user-friendly design is required, it has to be obvious to all that plastics play an important role. 

Product designers must consider the conditions under which fabrication will take place, because these conditions affect part performance and cost (Chapter 7). Such factors as production quantity, labor, and material cost are vital. Designers should also visualize how each part is to be fabricated. If they do not or cannot, their designs may not be satisfactory or even feasible from a production standpoint. One purpose of this book is 

Although there is no substitute for individual action based on a firm philosophical and ethical foundation, designers have developed guidelines for professional conduct based on the experience of many of them who have had to wrestle with troublesome ethical questions and situations previously. These guidelines can be found in the published codes of ethics for designers and engineers of a number of industry and technical societies. 

The use of computers in design and related fields is widespread and will continue to expand. It is increasingly important for designers to keep up to date continually with the nature and prospects of computer technologies. For example, plastics databases, accessible 

Computer-integrated manufacturing (CIM) is the. coordination of all stages of manufacturing, which enables the manufacturers to custom design products efficiently and economically, by a computer or a system of computers. 

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Haut, D. Success by Design. Medical Device Diagnostic Industry, pp. 48-60, Sept. 1988. 

Chemical reaction engineering is part of chemical engineering in general. It aims at controlling the chemical conversion on a technical scale and will ultimately lead to appropriate and successful reactor design. An important part is played by various factors, such as flow phenomena, mass and heat transfer, and reaction kinetics. It will be clear that in the first place it is necessary to know these factors separately. 

Pf = final, or last-stage discharge pressure, psia 1,2,. . . i = successive interstage designations Loj, Loj. . . LOf = loss factors designated by cylinder stages... 

Multilayer coatings or hlms have been proven to be successful in various applications, especially for wear protection. In multilayer systems, the intrinsic stress can be effectively reduced by designing interface number and composite materials in terms of the application and process technique. Therefore, the multilayer technique by which a specihe functional composite is able to approach received more attention for many years [17,18]. Here we introduce the results on microscale friction and scratch of DLC/DLC and Fe-N/TiN multilayers. 

Ikegashira et al. reported another recent example of the successful exploitation of conformational locks. They describe the discovery of a novel class of hepatitis C virus NS5B RNA polymerase inhibitors [42]. By designing and synthesizing conformationally constrained analogs of 40 (see Fig. 8.9), they obtained a series of novel compounds with significantly improved potency. Compound 41 was, for example, shown to be 7-fold more potent, see Fig. 8.9. 

This chapter is the first chapter in this book and serves as an introduction The first section of this chapter starts with a discussion of what is a medicinal chemist In this chapter the reader will notice far more attention to the people aspect of the discipline of medicinal chemistry than will be found in later chapters. This is by design. When expert practitioners in the field discuss success in medicinal chemistry the focus is usually very much on the person rather than on the technology. We admire the persistent drug hunters. We remember the individuals who do not give up easily. We appreciate those individuals with the interpersonal skills that facilitate an effective therapeutic project team. We admire those medicinal chemists who think out of the box and come up with the insights that transform a program. In this introduction I have tried to give some credit to this people factor. 

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