Sublimaze - Fentanyl

Sublimaze fentanyl. substance K neurokinin A neuropeptide K. substance P (SP) is a naturally occurring 11 amino acid residue C-terminally amidated peptide, and is a tachykinin present in the brain of vertebrate species, in spinal ganglia and in the intestines. It is formed from the precursor preprotachykinin A (PPT-A). It acts as a tachykinin RECEPTOR AGONIST and Stimulates extravascular smooth muscle, is a powerful VASODILATOR and transient HYPOTENSIVE, and causes salivation and increased capillary permeability. Notably, Af-terminally deleted fragments (e.g. SP(4-11)) are as active as substance P itself on many systems. It is used as a pharmacological tool. 

Sublimaze (Fentanyl citrate), Janssen-Cilag Ltd, UK Summary of product characteristics, January 2005. 

A patient is prescribed fentanyl (Sublimaze) 50 meg IM 30 minutes before surgery. The nurse has available a vial with a dosage strength of 0.05 mg/1 mL. The nurse calculates the dosage and administers. ... 

Fentanyl was introduced to the United States in 1968 by the Janssen Pharmaceutical Company and marketed under the trade name Sublimaze. Its primary purpose was for use as an intravenous anesthetic and analgesic. It is 100 times more potent than morphine in reducing pain, and its duration of action is only 30 minutes (compared to morphine, which lasts several hours). Over the years, fentanyl has proved to be an extremely useful drug, and to date, it is still widely used for surgeries, childbirth, pain associated with cancer and other diseases, and the treatment of trauma-related injuries. Although fentanyl solutions are often given intravenously, pill forms of the drug are also available. 

Reduction of Schiff base (XXXI) formed between l-phenethyl-4-piperidone and aniline, and acylation of the resultant dibase gives the highly potent analgesic [112] fentanyl(Sublimaze,XXXIla). In mice (tail-clip method), fentanyl... 

Fentanyl (Sublimaze) and its related phenylpiperidine derivatives are extremely potent drugs. They are used as adjuncts to anesthesia, and fentanyl may be given trans-dermally as an analgesic and as an oral lozenge for the induction of anesthesia, especially in children who may become anxious if given IV anesthesia. 

Parenteral (generic, Sublimaze) 50 mcg/mL for injection Fentanyl Transdermal System (Duragesic) 12.5, 25, 50, 75, 100 mcg/h delivery Fentanyl Buccal 100, 200, 400, 600, 800 meg oral lozenge Fentanyl Actiq 200, 400, 600, 800, 1200, 1600 meg lozenge on a stick Patient Controlled Transdermal Iontophoretic Fentanyl System 40 meg per dose for delivery Hydromorphone (generic, Dilaudid)... 

Designated synthetic drugs levomethadyl (Orlaam), meperidine (Demerol), methadone, levorphanol (Levo-Dromoran), fentanyl (Sublimaze, Duragesic, Actiq), alphaprodine, alfentanil (Alfenta), sufentanil (Sufenta), remifentanil (Ultiva)... 

Fentanyl derivatives [Sublimaze, others] Hydromorphone [Dilaudid, Hydrostat] Levorphanol [Levo-Dromoran] Meperidine [Demerol]... 

Stuff see Heroin Steroids Stupefi see Rohypnol Stupefy see Benzodiazepine Sublimaze see Fentanyl Substance see BenzylpiperazinefTrifluo-romethylphenylpiperazine Sucol B see GBL... 

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