Styryl

An alkyi group occupying the 4-position of the thiazole ring may condense if the 5-position is substituted. 2-Acetamido-4-methy]-5-nitrothiazole (80) and p-cyanobenzaldehyde when refluxed with small amounts of piperidine yield the 4-styryl derivative (81) (Scheme 57) (238, 239). 

The electron impact mass spectrometric fragmentations of (E)-3- and ( )-4-styryl-pyridazines show that the intensity ratio of the M and (M -1)" ions, the general degree of fragmentation and the elimination pathways of nitrogen are the most characteristic features distinguishing between the two isomeric compounds (81JHC255). 

Pyrylium salts, 2,3,4,6-tetramethyl-synthesis, 3, 868 Pyrylium salts, 2,4,6-trialkyl-oxidation, 3, 650 Pyrylium salts, 2,4,6-triaryl-synthesis, 3, 870 Pyrylium salts, 2,4,6-trimethyl-deuteration, 3, 649 synthesis, 3, 861, 868, 873 Pyrylium salts, 2,4,6-trimethyl-4-styryl-reactions... 

Under the same conditions, 4-styryl nitrobenzene (4-nitrostilbene) undergoes cis-to-trans isomerization only, with no changes in the nitro group (Todres et al. 1984, 1985 Scheme 1.9). 

Ruhland et al. used PdCl2(dppf)-NEt3 Heck conditions to add to a resin-bound aryl iodide, thereby generating supported 4-styryl (3-lactams, as shown in Scheme 17.45 This catalyst system, also found to be effective for the Suzuki reaction (see Section 2.4), is unusual for the Heck reaction and had only previously been used for an intramolecular cyclization.46 The more usual conditions of Pd(OAc)2/phosphine/NEt3 or K2C03 were found to be ineffective. 

In contrast to the preferential attack on ring atoms at C-2 by nucleophiles (Section 2.23.2.3.2), a substituent at C-4 is more susceptible (than if it were at C-2) to attack by an electrophile such as a carbonyl compound. Thus, 2,4,6-trimethylpyrylium perchlorate (107) yields the coloured 4-styryl derivative (109) as the only product of reaction with a benzaldehyde (67JOU1809, 71T3503) but a 2-methyl group in cations such as 4,6-diphenyl-2-methylpyrylium (108) also reacts reaction at a second methyl group in (107) requires drastic conditions (72BSF3173). 

Moreover, high enantioselectivity has been reported for an MIP that was selective for Z-glutamate [33]. Here, changes in the UV-vis absorbance of the l-(4-styryl)-3-(3-nitrophenyl)urea monomer were monitored, as opposed to the previous studies where the intrinsic absorbance of the template was measured. The UV-vis spectroscopy titration of the functional monomer with different concentrations of the template in solution led to a bathochromic shift from 349 to 364 nm. The colour change of both the solution and the resulting bulk polymer upon addition of Z-glutamate was visible even to the naked eye, with a 1 1 monomer-to-template ratio demonstrated. 

Styryl substituted 1,4-dihydropyrimidine 352 treated with hydrogen chloride gas in chloroform leads to a complicated polyheterocyle 354 [379]. The mechanism of the reaction most likely involves formation of a benzyl cation 353 followed by a nucleophilic attack of the aminocrotonate moiety. 

Fluorostyryl)coumarin (1) 4-(4-Fluorostyryl)coumarin (2) 4-(4-Fluorostyryl)-6-fluocoumarin (3) 4-(2,6-Difluorostyryl)-6-fluocoumarin (4) 4-(2-Fluorostyryl)-6-fluocoumarin (5) 4-(2,6-Difluorostyryl)-7-fluocoumarin (6) 4-(2,6-Difluorostyryl)coumarin (7) 4-(3-Fluorostyryl)coumarin (8) 4-(3-Fluorostyryl)coumarina (8) 4-Styryl-6-fluorocoumarin (9) 4-Styryl-7-fluorocoumarin (10)... 

The /nms- as-4-styrylpyridine isomerization is up-hill energetically by 2 kcal/mole,123 and, therefore, such an isomerization represents movement away from the thermodynamic ratio of these two isomers. Photolysis at 436 nm of ClRe(CO)3(fnms-4-styryl-pyridine)2 was found to ultimately yield completely (sequentially ) ClRe(CO)3 (c -4-styrylpyridine)2. Further, the coordinated cfs-4-styrylpyridine could be exchanged thermally with excess tazns-4-styrylpyridine in the medium, and the sequence of events in reactions (36)—(39) was proposed123 to account for the photoinduced iso-... 

Benzaldehyde takes part in condensation reactions with the methyl groups of 2,4-dimethylbenzodiazepine in the presence of base with aqueous alkali a mixture of mono- and di-condensation products are formed, with sodium ethoxide in ethanol only the di-condensation product, 2,4-dis-tyrylbenzodiazepine, is formed (59JCS1132 66MIl).The resultant products are yellow and with mineral acids give, respectively, purple (2-methyl-4-styryl) and green (2,4-distyryl) salts. When the distyryl compound is treated with aqueous alkali, it is partially hydrolyzed to the 2-methyl-4-styryl derivative (59JCS1132). 

Styryl isocyanates 183, readily available by Curtius rearrangement of cinnamoyl azides, undergo thermal or Friedel Crafts cyclization to 1-isoquinolones 184 (Scheme 110). 

A full assignment of the proton resonance of substituted 2-styryl-5-nitroimidazoles was carried out by the use of an addition increment method for chemical shift prediction [353]. Some 4-styryl-5-nitroimidazoles have been studied in [354],... 

Tsuji-Trost allylation reactions offer multiple pathways to tetrahydrofuran synthesis including C-C bond-formation steps. A palladium-catalyzed sequence of allylic alkylation and Hiyama cross-coupling provides a convenient synthesis of 4-(styryl)-lactones (Scheme 67) <2006SL2231>. 

Ahluwalia VK, Kaila N, Bala S (1987) Synthesis and antifungal and antibacterial activities of some 2-amino-4, 6-substituted-pyrimidines and 4-styryl-6, 7-pyranocoumarins. Indian J Chem Sect B 26B 700-702... 

DXG025 CAS 2583-80-4 HR 1 DISODIUM 2-(4-STYRYL-3-SULFOPHEN-YL)-7-SULFO-2H-NAPHTHO(1,2-d)TRIAZOLE... 

SYNS 2H-NAPHTHO(l,2-d)TRIAZOLE, 2-(4-STYRYL-3-SULFOPHENYL)-7-SULFO-, DISODIUM SALT NAPHTHO(l, 2-d)TRIAZOLE-7-SULFONIC ACID,2-(4-(2-PHENYLETHENYL)-3-SULFOPHENYL)-, DISODIUM 2-STILBENESULFONIC ACID, 4-(7-SULFO-2H-NAPHTHO(l,2-d)TRIAZOL-2-YL)-, DISODIUM SALT... 

Richards and Stevens reported the reaction of 2-methylquinolizinium salt with p-dimethylaminobenzaldehyde and p-dimethylaminonitrosoben-zene in the presence of piperidine to yield 2-styryl derivative 317 and anil 318, respectively (58JCS3067). A 2-phenyl-4-methyl derivative also condensed with p-dimethylaminobenzaldehyde to give a 4-styryl derivative (58%), while a 4,6-dimethyl-2-phenyl derivative did not because of steric hindrance. The reaction with 2,4,6-trimethylquinolizinium salt occurred only at the 2-position (63%) (63JOC393). 

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