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Strychnine paralysis

Maqianzi, the dried ripe seed of S. nux-vomica contains 1.0-1.4% each of strychnine and brucine. It has been used as a herbal remedy for rheumatism, musculoskeletal injuries, and limb paralysis. [Pg.2158]

Derived from Carolina jasmine (Gelsemium sem-pervirens). Large doses have strychnine-like effects. Respiratory failure, dilated pupils, paralysis of eye movements, convulsions, death. 11 mg said to have killed a healthy woman. [Pg.684]

One of three alkaloids extracted from the bark of the Brazilian tree pereira (Geissospermum laeve). Said to act like strychnine details lacking. Geissospermine causes death by paralysis, pereirine causes paralysis, fever, and death, Vellosine is also present but its toxicity is not reported. [Pg.696]

Strychnine (1), the active component of a notorious arrow poison in Southeast Asia, has a mysterious history. [1] It is a convulsant blocking synaptic inhibition in the spinal cord by acting as an antagonist of the inhibitory neurotransmitter, glycine. [2] In therapeutic doses strychnine has a mildly analeptic effect in toxic doses it leads to uncoordinated tonic convulsions induced by acoustic, tactile, or optical stimuli. Paralysis of the respiratory organ results in death 100-300 mg is the lethal dose fiir an adult human. [2c]... [Pg.270]

Hydrastine resembles strychnine in some of its responses (295), producing convulsions in the frog which may be followed by paralysis. Unlike narcotine, which is a depressor, hydrastine has a pressor effect (296, 297, 298). It is more toxic than narcotine (296) or morphine (299), has a paralytic action on intestines (296, 300), and inhibits the contraction of smooth muscles (251, 252, 254, 301). It is strongly antagonistic to adrenaline, totally suppressing the renal vasoconstriction due to small doses of the latter (302-305). It is slightly antispasmodic (306) and has a mild sedative effect on respiration by diminishing the amplitude and frequency (307). [Pg.190]

Strychnine (CAS 57-24-9) Neurotoxin binds to inhibitory, postsyn-aptic glycine receptors, which results in excessive motor neuron activity associated with convulsions and muscular hyperrigidity leading to respiratory impairment or paralysis. See also p 348. [Pg.614]

Brucine 2,3-dimethoxystrychnine, M, 394.47, m.p. 105 °C (tetrahydrate), 178 °C (anhydrous). It is used in preparative chemistry to separate racemic acids into optical isomers. B. has one tenth of the toxicity of strychnine, from which it is derived. The main physiological effect is paralysis of smooth musculature. For formula and biosynthesis, see Strychnos alkaloids. [Pg.79]

In current scientific usage, curare refers only to those C. a. with muscle-relaxing (paralysing) effects, namely the dimeric indole alkaloids with a strychnine skeleton and two quaternary nitrogens. These compounds are extremely poisonous calabash alkaloids E and G cause death by respiratory paralysis and are among the most toxic compounds known. [Pg.146]

Brucine is a dimethoxy form of strychnine and reported to possess antitumor and anti-angiogenic activities in vitro and in vivo [144]. Brucine causes paralysis of peripheral motor nerve without mediating the convulsive action characteristic of strychnine [118]. It is reportedly less toxic than strychnine. [Pg.600]

The securinega alkaloids occur in several species of the Securinega and Phyllan-thus genera (150). Securinine was first isolated from the leaves and stems of Securinega suffruticosa (Euphorbiaceae). Securinine nitrate is a central nervous system stimulant similar to strychnine but less toxic. It was found to be useful in treatment of paresis and paralysis following infectious diseases and psychic disorders. The related alkaloids were obtained from Securinega suffruticosa allose-curinine, dihydrosecurinine, securinol A, and securinol B from the leaves, and securitinine from the roots. [Pg.208]


See other pages where Strychnine paralysis is mentioned: [Pg.167]    [Pg.596]    [Pg.1174]    [Pg.120]    [Pg.275]    [Pg.280]    [Pg.266]    [Pg.264]    [Pg.264]    [Pg.264]    [Pg.531]    [Pg.107]    [Pg.224]    [Pg.3]    [Pg.1174]    [Pg.163]    [Pg.200]    [Pg.201]    [Pg.623]    [Pg.3186]    [Pg.2820]    [Pg.135]    [Pg.266]    [Pg.108]    [Pg.579]    [Pg.370]    [Pg.395]    [Pg.1571]    [Pg.55]    [Pg.608]    [Pg.310]    [Pg.508]    [Pg.217]    [Pg.217]    [Pg.636]    [Pg.117]   
See also in sourсe #XX -- [ Pg.107 ]

See also in sourсe #XX -- [ Pg.107 ]




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