Structure teratogenicity relationship

Eikel, D., Lampen, A. and Nau, H. (2006) Teratogenic effects mediated by inhibition of histone deacetylases evidence from quantitative structure activity relationships of 20 valproic add derivatives. Chemical Research in Toxicology, 19, 272-278. 

DiCarlo, F.J. (1990) Structure-activity relationships (SAR) and structure-metabolism relationships (SMR) affecting the teratogenicity of carboxylic acids. Drug Metab. Rev.,... 

Woo, Y.-T. (1983) Carcinogenicity, mutagenicity and teratogenicity of carbamates, fhiocarbamates and related compounds an overview of structure-activity relationships and environmental concerns. Environ. Carcinog. Ecotoxicol. Rev., Cl (1), 97-133. 

Francis BM, Metcalf RL. 1984. Structure activity relationships in diphenyl ether teratogenicity. Teratology 29 29A. 

Lewis DF, Ioannides C, Parke DV. A quantitative structure-activity relationship (QSAR) study of mutagenicity in several series of organic chemicals likely to be activated by cytochrome P450 enzymes. Teratogen Carcinogen Mutagen 2003 (Suppl)l 187-93. 

Klopman G, Ptchelintsev D. Antifungal triazole alcohols a comparative analysis of structure-activity, structure-teratogenicity and structure-therapeutic index relationships using the multiple computer-automated structure evaluation (Multi-... 

Dawson DA, Schultz TW, Hunter RS. Developmental toxicity of carboxylic acids to Xenopus embryos A quantitative structure-activity relationship and computer-automated structure evaluation. Teratogen Carcin Mut 1996 16 109-24. 

Rawlings SJ, Shuker DEG, Webb M, et al. 1985. The teratogenic potential of alkoxy acids in postimplantation rat embryo culture Structure-activity relationships. Toxicol Let 28 49-58. 

Currently, QSAR (quantitative structure-activity relationship) and SAR (structure-activity relationship) methods are widely used for computational prediction of different toxicity types, such as caidio-, hepato-, renal toxicity, teratogenicity, and carcinogenicity. 

Acute and subchronic toxicity, teratogenicity, and biochemical mechanism studies of a series of structurally similar aliphatic nitriles indicated that although the toxicological profiles were generally the same for most of the compounds, there were unique differences, too (Johannsen and Levinska, 1986). In this respect, acetonitrile was different from the other nitriles within the homologous series. Nitriles liberated cyanide both in vivo and in vitro. Tanii and Hashimoto (1984a,b, 1985) observed a dose-cyanide liberation relationship in liver and hepatic microsomal enzyme system in mice pretreated with carbon tetrachloride. For most nitriles, the toxicity was greatly reduced by carbon tetrachloride pretreatment. By contrast, certain nitriles, exhibited an increase of toxicity as a result of such pretreatment. 

Keeler, R. F. (1978). Cyclopamlne and related steroidal alkaloid teratogens Their occurrence, structural relationship and biologic effects. Lipids, 13 708-715. 

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