Structure-function relation

The structural characteristics of individual PCB congeners influence their induction of various P450 activities. In mammals, PCB congeners have been characterized as 3-methylcholanthrene-type inducers, phenobarbital-type inducers, or mixed-type inducers of both. AHH and EROD activities (which are preferentially catalyzed by the P450IA gene subfamily) have been induced by planar PCBs in fish and mammals and by some mono- and di-ortho analogs of planar PCBs in mammals. The mechanism of toxic action of planar and mono-ortho planar PCBs is linked to an interaction with the 2,3,7,8-TCDD (or Ah) receptor protein. But this mechanism does not account for all observed PCB toxici-ties. Toxic responses uiuelated to Ah receptor effects have been reported of PCBs 4, 28, 31, 49, 52, 84, 95, 110, 136, and 153. For example, PCB 153 is less cytotoxic than PCB 169 

PCB 156, a mixed inducer of microsomal enzymes, significantly increases the incidences 

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Lindskog S (1970) Cobalt(II) in Metalloenzymes. A Reporter of Structure-Function Relations. 8 153-196 Ling JH, see Hall DI (1973) 15 3-51... 

There are many ligands and group-specific reagents that have been demonstrated to alter the properties of H,K-ATPase, and which are not clinically useful. For example, there is a variety of chemicals that have been used in studies on structure-function relations of H,K-ATPase and that inhibit the enzyme in vitro by modification of its amino [49,67,158], sulfhydryl [95,165,166] or carboxyl groups [140]. 

For an example of parallel claims about multiple realizability in psychology and its consequences, see Bechtel and Mundale (1999). As Van Regenmortel (1999) has remarked with respect to structure-function relations ... 

Daage, M., and Chianelli, R. R., Structure-Function Relations in Molybdenum Sulfide Catalysts The Rim-Edge Model. J. Catal., 1994. 149 pp. 414-427. 

Summary of PCB structure-function relations in rats (Rattus sp.)... 

Table 24.5 Summary of PCB Structure—Function Relations in Rats fiattus sp.)... 

Ballesteros, J. and Weinstein, H. (1995) Integrated methods for the construction of three-dimensional models of structure-function relations in G protein-coupled receptors. Methods Neurosci. 25, 366-428. 

Tyler-Cross, R., M. Sobel, L.E. McAdory, and R.B. Harris. 1996. Structure-function relations of antithrombin Ill-heparin interactions as assessed by biophysical and biological assays and molecular modeling of peptide-pentasaccharide-docked complexes. Arch Biochem Biophys 334 206-213. 

Probing Structure-Function Relations in Ferritin and Bacterioferritin... 

A. J. Bearden, W. R. Durnham Iron Electronic Configurations in Proteins Studies by Moss-bauer Spectroscopy. - K Wiitkrich Structural Studies of Hemes and Hemoproteins by Nuclear Magnetic Resonance Spectroscopy. -H. A 0. Hill,A. Roder, R. J. P. Williams The Chemical Nature and Reactivity of Cytochrome P-450. - S. Lindskog Cobalt (II) in Metalloenzymes. A Reporter of Structure-Function Relations. 

The determination of the crystal structure of carboxypeptidase A and its complex with glycyl-L-tyrosine has been completed to 2.0 A resolution by Lipscomb and coworkes (91). A detailed description of the molecule including a comprehensive discussion of structure-function relations have been presented (91). 

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