Combinatorial chemistry, drug

Nicolaou, K.C., Hanko, R., Hartwig, W., eds., Handbook of Combinatorial Chemistry, Drugs, Catalysts, Materials, Vol. 1, Wiley-VCH, Weinheim, 2002. 

T. Weskamp, in K.C. Nicolaou, R. Hangko, W. Hartwig (Ed.), Handbook of Combinatorial Chemistry - Drugs, Catalyst, Materials. Wiley, New York, 2002. 

Keifer P, Eligh-resolution NMR techniques for solid-phase synthesis and combinatorial chemistry, Drug Discovery Today, 2(11) 468 478, 1997. 

F. A1 Obeidi, J. A. Ostrem, Factor Xa inhibitors by classical and combinatorial chemistry. Drug Discovery Today 1998, 3, 223-231. 

The subsequent chapters describe the role of mass spectrometry in the drug discovery process in greater detail. Initial chapters deal more with instrumentation and sample preparation as they relate to mass spectrometry. The remaining chapters describe the utility of mass spectrometry in different areas of the drug discovery process, such as combinatorial chemistry, drug transport, drug metabolism, pharmacokinetics, and microdialysis. 

Sorafenib is the first de novo combinatorial chemistry drug... 

In a typical combinatorial chemistry drug-discovery protocol, a large array of compounds, called combinatorial libraries, are produced and tested for high-affinity binding to enzymes, receptors, or antibodies. The compounds that provide a hit with the target are selected and further developed into leads. Further optimization of leads narrows the potential drug candidates to one or... 

Nicolaou KC, Pfefferkorn JA. A solid-phase S3uithesis of natural products and natural product-like libraries. In Nicolaou KC, Hanko R, Hartwig W, editors. Handbook of combinatorial chemistry drugs, catalysts and materials. Volume 2. Weinheim Wiley-VCH 2002 p 613-642. 

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