Structure and topology

The examples just presented give initial impressions of how DNA can be utilized as a template in the synthesis of nanometric and mesoscopic aggregates. However, the studies emphasize the importance of fundamental research on the interaction between DNA and the various binders, such as metal and organic cations. Of particular importance are the consequences of binding events on the structure and topology of the nucleic acid components involved. 

Clearly, this is a rich playground for chemists interested in novel 7r-structures and topologies, and it is likely that many novel radialene-derived compounds will be prepared in the not too distant future. 

Jones, D., Taylor, W., and Thornton, J. (1994). A model recognition approach to the prediction of all-helical membrane protein structure and topology. Biochemistry 33, 3038-3049. 

The applicability of Eq. (45) to a broad range of biological (i.e., toxic, geno-toxic) structure-activity relationships has been demonstrated convincingly by Hansch and associates and many others in the years since 1964 [60-62, 80, 120-122, 160, 161, 195, 204-208, 281-285, 289, 296-298]. The success of this model led to its generalization to include additional parameters in attempts to minimize residual variance in such correlations, a wide variety of physicochemical parameters and properties, structural and topological features, molecular orbital indices, and for constant but for theoretically unaccountable features, indicator or dummy variables (1 or 0) have been employed. A widespread use of Eq. (45) has provided an important stimulus for the review and extension of established scales of substituent effects, and even for the development of new ones. It should be cautioned here, however, that the general validity or indeed the need for these latter scales has not been established. 

CoMFA, Molconn-Z, Volsurf (and other related products) Tripos Inc. www.tripos.com A variety of descriptors, including comparative molecular field analysis physicochemical properties and molecular, structural, and topological descriptors... 

Smedberg, A. Hjertberg, T. Gustafsson, B. Effect of molecular structure and topology on network formation in peroxide cross-linked polyethylene. Polymer 2003, 44, 3395-3405. 

F. M. Marassi and S. J. Opella, A solid-state NMR index of helical membrane protein structure and topology. J. Magn. Reson.. 2000,144, 150-155. 

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