Structure and Autoregulation of CaM Kinase II

From a regulatory point of view, CaM kinase II is of particular interest as it has the characteristic of an enzyme with a built-in memory switch . The memory allows the CaM kinase to conserve a stimulatory signal over a longer period of time and to remain in an activated state, even when the initiating stimulus has died away. 

CaM kinase is regulated by both autophosphorylation and by Ca Vcahnodulin. An N-terminal catalytic domain, a regulatory domain and an association domain can be 

AcetylCoA carboxylase Glycogen synthase HMGCoA reductase NO synthase Biosynthesis of fatty adds Glycogen synthesis Biosynthesis of cholesterol Biosynthesis of NO  

Ca channel (N-type) Ca ATPase (heart) Synaptogamin Presynaptic Ca influx Storage of Ca Release of neurotransmitters  

Ryanodin receptor p56 Lck tyrosine kinase EGF receptor Cychc nucleotide phosphodiesterase Phosphohpase A2 Ribosomal protein S6 Release of Ca Activation of T cells Growth control cAMP and cGMP metabolism Hydrolysis of phospholipids Protein biosynthesis  

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