Analogue of Substrates as Inhibitors

Fluorophosphonates, fluoro-C-glycosides, and difluorodisaccharides can be used as nonhydrolyzable and stable mimics of phosphates, sulfates, and disaccharides, where the anomeric oxygen is replaced by a CHF or a CF2 group. 

The difluorophosphonates have been the subject of a great number of studies due to their potential application in the inhibition of numerous phosphatases and 

The replacement of the anomeric oxygen of C-glycosides and C-disaccharides by a CF2 leads to difluoro-C-glycosides, difluoro-C-disaccharides, and difluoro-C-glyco-peptides. These hydrolytically stable compounds have been synthesized, but their use as inhibitors does not seem to have been biologically validated.  

---