Structural relatedness

Jenkins, J. A., Griffiths-Jones S, Shewry, P.R., Breteneder, H. and Mills, E.N.C., Structural relatedness of plant food allergens with specific reference to cross-reactive allergens An in silico analysis. J. Allergy Clin. Immunol., 115, 163, 2005. 

E. colt had a Mr of 110 kDa. It also could be bound to Avicel, but its structural relatedness to Cex and CenA has not yet been determined. A deletion mutant of cenB encoded a polypeptide of Mr 70 kDa. The missing segment represented the carboxyl terminal 40 kDa or CenB. The 70 kDa fragment had enzymatic activity and it could still bind to substrate (11). The nature and function of the 40 kDa carboxyl terminus of CenB are being determined. 

A Study Figs. 4.1-43 and convince yourself of the structural relatedness of all of the cube structures and of all of the hexagonal structures. 

Jollfes, P., Loucheux-Lefebvre, M. H. and Henschen, A. 1978. Structural relatedness of K-casein and fibrinogen 7-chain. J. Mol Evol 11, 271-277. 

A similar situation exists with the K5 antigen. Figure 15 shows that this capsular polysaccharide is practically identical with a precursor of heparin. It was in fact shown recently that the K5 polysaccharide is a substrate for the de-N-acetylase which initiates the processing of this precursor to heparin. Structural relatedness may not be the only cause for the very low immunogenicity of a coli capsular antigen, but it appears quite suggestive. 

Uptake blocker (Table 12) display a certain degree of structural relatedness to the endogenous neurotransmitter whose transport is inhibited dopamine uptake by the anonaine, cocaine, ibogaine, and salsolinol (see Scheme II) serotonin by 12-hydroxyibogaine, ibogaine, and norharman noradrenaline and adrenaline by cathinone, ephedrine, salsolinol GABA by arecaidine, and guvacine. Reserpine and deserpidine... 

Stavrrezer, E., Brodeur, D. Brennaa LA. (1989). The v-ski oncogene ertcodes a truncated set of c-ski coding exons with limited sequertce ar d structural relatedness to v-myc. Mol. Cell. Biol., 9, 4038-45. 

The A -stearoyl (18 0)-ACP desaturase is found in nearly all plant tissues. In addition, several other acyl-ACP desaturases have been identifi in plants, including the A -palmitoyl (16 0)-ACP desaturase of coriander seed (1), the A -16 0-ACP desaturase of Thunbergia data seed (2), and the A -myristoyl (14 0)-ACP desaturase of geranium trichomes (3). These enzymes share >70% amino acid sequence similarity. Given this high degree of structural relatedness, comparisons of the amino acid sequences of these enzymes may provide clues as to which residues dictate the fatty acid chain-length and double bond positional specificities of acyl-ACP desaturases, especially when used in conjunction with the recently determined crystal structure of the A -18 0-ACP desaturase (4). 

Study Figs. 4.I-4.3 and convince yourselT of the structural relatedness or all oT the cubic structures and oT all or the hexagonal structures. 

Walderhaug MO, Post RL, Saccomani G, et al. Structural relatedness of three ion-transport adenosine triphosphatases around their active sites of phosphorylation. J Biol Chem 1985 260 3852-3859. 

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