Structural organization, human

T12. Tanoue, A., Endo, F and Matsuda, I., Structural organization of the gene for human prolidase (peptidase D) and demonstration of a partial gene deletion in a patient with prolidase deficiency. J. Biol. Chem. 265,11306-11311 (1990). 

Johnson MR, Wang K, Tillmanns S et al. Structural organization of the human dihydropyrimidine dehydrogenase gene. Cancer Res 1997 57 1660-1663. 

Miyamoto K, Kesterson RA, Yamamoto H, Taketani Y, Nishiwaki E, Tatsumi S, Inoue Y, Morita K, Takeda E, Pike IW. Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol 1997 11(8) 1165-1179. 

Snell K, Baumann U, Byrne PC, Chave KJ, Renwick SB, Sanders PG, and Whitehouse SK (2000) The genetic organization and protein crystallographic structure of human serine hydroxymethyltransferase. Advances in Enzyme Regulation 40, 353-403. 

Kolodziej SJ, et al. The three-dimensional structure of die human alpha 2-macroglobulin dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes. J. Biol. Chem. 2002 277 28031-28037. 

Soininen, R., Huotari, M., Ganguly, A., Prockop, D. J. and Tryggvason. K. (1989). Structural organization of the gene for the alpha chain of human type IV collagen. J. Biol. Chem. 264(23), 13565-13571. 

Armesilla AL, Vega MA Structural organization of the gene for human CD36 glycoprotein. J Biol Chem 269 18985-18991,1994... 

Izzo P, Costanzo P, Lupo A, Rippa E, Paolella G, Salvatore F. Human aldolase A gene. Structural organization and tissue-specific expression by multiple promoters and alternate mRNA processing. Eur J Biochem 1988 174 569-78. 

Kelner MJ, Montoya MA. Structural organization of the human glutathione reductase gene determination of correct cDNA sequence and identification of a mitochondrial leader sequence. Biochem Biophys Res Commun 2000 269 366-8. 

DNA in mammalian cells is organized in complex structures called chromosomes (prokaryotes do not have a nucleus, do not divide by mitosis, and do not, strictly speaking, have chromosomes). The DNA in the chromosomes of human and other eukaryotic cells is intimately associated with two classes of proteins called histones and nonhistones. Collectively, DNA, histones, and nonhistones constitute chromatin, from which the name chromosome is derived. The DNA in a chromosome is an extremely long, linear molecule that must be condensed and organized to fit into the chromosomes in the nucleus. (The DNA in the 46 human chromosomes would be about 1 m long if fully extended.) Histones are responsible for the structural organization of DNA in chromosomes the nonhistone proteins... 

Social organization Structure of human society based on relationships among members and hierarchical arrangements. 

A hierarchical view is need to achieve the stratification. The concept of hierarchy is in fact a common feature of thinking about systems, so it is worth pursuing what Kumar, Smith, and Stefanelli were thinking as an example of what this means. The hierarchy is a tree-shaped graph that has several main components of a typical health organization or institution, namely its physical structures, its human resources, the tasks capable of being performed by these human resources, and the tasks recommended in the guidelines themselves. 

Moniaux N, Escande F, Porchet N, et al. Structural organization and classification of the human mucin genes. Front Biosci. 2001 6 D1192-D1206. 

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