Structural Features of the Human Tissue Kallikrein Genes and Proteins

Structural Features of the Human Tissue Kallikrein Genes and Proteins 

Extensive analyses over the last few years have led to the identification of many common structural features of kallikreins. Some of these features are shared with other members of the SI family of serine proteases (see 

Summary of Human Tissue Kallikrein Protein Characteristics 

Protein name pl MW Full length Signal peptide Activation peptide Mature protein Cysteines Substrate specificity5 

The crystal structure has been revealed for some rodent kallikreins. The three-dimensional structure of a horse orthologue of the human hK3 has also been reported [28]. In contrast, hKl and hK6 are the only human kallikreins for which crystal structures have been determined [48-50]. Most of the discussion in this section is derived from comparative model building of the human kallikrein proteins. 

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