Kallikreins structural features

Structural Features of the Human Tissue Kallikrein Genes and Proteins. 20... 

Extensive analyses over the last few years have led to the identification of many common structural features of kallikreins. Some of these features are shared with other members of the SI family of serine proteases (see... 

Yousef GM, Diamandis EP. Human kallikreins Common structural features, sequence analysis and evolution. Curr Genomic 2003 4 147-165. 

Kallikreins can be roughly divided into two categories, the classical kallikreins (hKl, hK2, and hK3) and the new kallikreins. The new kallikreins appear to be unique in their three-dimensional structure and share some features with trypsins and other features with the classical kallikreins. Comparative protein models show that the pattern of hydrophobic side-chain packing in the protein core is nearly identical in all human kallikreins, and the observed differences occur within the solvent-exposed loop segments. 

From a structural point of view, kallikreins belong to the serine protease family of enzymes. The essential features of serine proteases that are preserved in the kallikreins can be summarized as follows only one serine residue of the protein is catalytically active two residues, a histidine and an... 

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