B cell lymphopoiesis

Nagasaw, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H., and Kishimoto T. (1996). Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382 635-638. 

Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996 382 635-8. 

Stromal derived factor. Involved in development of CNS and vasculature B-cell lymphopoiesis. Involved in the organization of secondary LN (ectopic LN in synovium)... 

Hardin, J.A., Hinoshita, F., and Sherr, D.H. Mechanisms by which benzo[a]pyrene, an environmental carcinogen, suppresses B cell lymphopoiesis, Toxicol. Appl. Pharmacol., 117, 155, 1992. 

B-cell lymphopoiesis in mouse bone marrow has been shown to be inhibited by incubation with fluoranthene In vitro at concentrations of >5 ig/mL (25 pmol). This effect on B- cell precursors may be mediated in part by a stimulation of programmed cell death, as demonstrated by the increase in DNA fragmentation induced by fluoranthene 15-17 hours after addition to the incubation medium. Furthermore, fluoranthene-induced DNA fragmentation always preceded fluoranthene-induced B-cell precursor death. Another mechanism for fluoranthene-induced inhibition of B-cell lymphopoiesis may be alterations in cell growth rates (fluoranthene was shown to slow the rate of B-cell precursor growth at concentrations <5 ig/mL) and/or altered cell survival (Hinoshita et al. 1992). 

Mouse CXCR4 No Abnormal Ventricular septal defect Impaired B cell lymphopoiesis Impaired bone marrow myelopoiesis Defective cerebellar and gastric vascular development... 

In animal models, the lack of either SDF-1 or CXCR4 exhibits an almost identical phenotype of late gestational lethality and defects in B cell lymphopoiesis, bone marrow colonization, and cardiac septum formation [13, 14]. These studies indicated that CXCR4 is essential for development, hematopoiesis, organogenesis, and vascularization [13-19], in addition to functioning as a classical chemokine receptor in adults [5, 19]. 

Seisdedos, F., and Emilie, D. (1999) Stromal cell-derived factor 1 (SDF-1) and antenatal human B cell lymphopoiesis expression of SDF-1 hy mesofhelial cells and hiliary ductal plate epithelial cells. Proceedings of the National Academy of Sciences of the United States of America, 96, 8585-8590. 

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