Streptomyces species 8. griseus

First among the aminoglycosides was streptomycin, one of several antibiotics isolated from Streptomyces species by Selman Waksman—this from S. griseus in 1944. Waksman proved to be an enormously effective seeker of antibiotics in natural products. In addition to streptomycin, he discovered neomycin, another widely used antibiotic. Less important discoveries include actinomycin, clavacin, streptothricin, grisein, fradicin, and candidin. Waksman received the Nobel Prize in Physiology or Medicine in 1952. 

The following Streptomyces species Streptomyces coelicolor, S. lividans, S. parvulus, and S. griseus. The following are accepted as vector components of certified Host-Vector... 

The elucidation of chemical structure of streptomycin, an antibiotic produced by Streptomyces griseus, and other streptomyces species has now been virtually completed. 

A low cobalt concentration was shown by Hendlin and Ruger (1950) to limit synthesis of vitamin Bi2. Cobalt comprises about 4% of the molecule. Working with 13 cultures, including a strain of Streptomyces griseus, unidentified rumen and soil isolates, a strain of Mycobacterium smegmatis, and Pseudomonas species, Hendlin and Ruger (1950) found that addition of 1 to 2 ppm of cobalt increased yield by threefold. 

Etamycin, viridogrisein a cyclic peptide lactone antibiotic from Streptomyces griseus and related species. It is effective against Gram-positive bacteria and Mycobacterium tuberculosis. 

The same peptide was isolated by Johnson et al. (324) from culture filtrates of an unidentified species of Streptomyces, and also from Strepto-myces griseus, and Aspergillus fumigatus H.S. The two latter are streptomycin-producing strains. The peptide appears in the culture mediumjonly after growth and is isolated in crystalline form. The cyclic peptide has been identified by its infrared spectrum and by its hydrolysis products, which were identified by paper chromatography. Isolation of leucine and proline and the determination of their rotatory power have shown that they are both in l form. 

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