Strategy structure-goal

Structure-goal strategies—directed at the structure of a potential intermediate or potential starting material. Such a goal greatly narrows a retrosynthetic search and allows the application of bidirectional search techniques. 

Structure-goal Strategy. The use of a particular structure corresponding to a potentially available starting material or synthetic intermediate as a guide for retrosynthetic search. 

Structure-goal strategies—directed at the structure of a potential intermediate or... 

Structure-goal strategies. Here a potential intermediate or starting compound aids in guiding the analysis. 

Structure goal strategies. Identify a potential starting material, building block, retrosynthetic subunit, or initiating chiral element (.see the chiral template approach in sec. 10.9). 

Critical elements in the architecture of organizations are goals, strategy, structure and culture. These are configured in particular ways in different... 

Safety assessment strategy (with Goal Structuring Notation)... 

Structural subgoals may be useful in the application of transform-based strategies. This is especially so with structurally complex retrons which can be mapped onto a target in only one or two ways. It is often possible in such cases quickly to derive the structure of a possible intermediate in a trial retrosynthetic sequence. For instance, with 109 as TGT the quinone-Diels-Alder transform is an obvious T-goal. The retron for that transform can readily be mapped... 

The synthesis of ovalicin was accomplished following a line of analysis which was totally different from that employed for the synthesis of the structural relative fumagillol. The plan for ovalicin was based on S-goal, appendage, stereochemical and functional group derived strategies. A key requirement for the synthesis was the stereospecific construction of the -l,4-pentadienyl subunit, which was achieved by a method of potentially wide utility. 

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