Strategy transform-based

Structural subgoals may be useful in the application of transform-based strategies. This is especially so with structurally complex retrons which can be mapped onto a target in only one or two ways. It is often possible in such cases quickly to derive the structure of a possible intermediate in a trial retrosynthetic sequence. For instance, with 109 as TGT the quinone-Diels-Alder transform is an obvious T-goal. The retron for that transform can readily be mapped... 

Transform-based Strategy. A strategic guide for retrosynthetic analysis in which the application of a particular powerfully simplifying transform becomes a goal. 

The essential features of the Masamune-Sharpless hexose synthesis strategy are outlined in a general way in Scheme 4. The strategy is based on the reiterative- application of a two-carbon extension cycle. One cycle comprises the following four key transformations (I) homologation of an aldehyde to an allylic alcohol (II) Sharpless asymmetric epoxidation of the allylic alcohol ... 

Some single examples of this type of reaction were discussed in earlier sections, but due to the importance of these transformations, an additional overview will be provided here. One of the first transformations based on this strategy was published by Inoue and coworkers [134] using propargylic alkoxide, an arylhalide or vinyl bromide and C02 to give cyclic carbonates. The Balme group used this ap-... 

Many successful chemical transformations based on the rich and multifaceted chemistry of nitrones underlie various synthetic strategies. 

In this context, value chain planning is the integration of volume and value decisions based on the value chain strategy transforming the company into a marketplace clearing supplier offers in procurement with customer demand in sales... 

The first total synthesis of a racemic dolastane (rac-llO) was apparently published by Pattenden as a short communication 1986 followed in 1988 by a full paper [77, 78]. Pattenden s strategy is based on an intramolecular [2+2]-photocycloaddition/cyclobutane fragmentation to transform the diene 133 into the hydroazulene 136 (Scheme 20). In between the cycloaddition... 

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