Structure-goal

Structure-goal strategies—directed at the structure of a potential intermediate or potential starting material. Such a goal greatly narrows a retrosynthetic search and allows the application of bidirectional search techniques. 

Structure-goal Strategy. The use of a particular structure corresponding to a potentially available starting material or synthetic intermediate as a guide for retrosynthetic search. 

Structure-goal strategies—directed at the structure of a potential intermediate or... 

Structure-goal strategies. Here a potential intermediate or starting compound aids in guiding the analysis. 

Structural goal no special initial specific (lead oriented)... 

Structure goal strategies. Identify a potential starting material, building block, retrosynthetic subunit, or initiating chiral element (.see the chiral template approach in sec. 10.9). 

RNA Structure prediction models represent a tractable method to realize this sequence-to-structure goal by balancing accuracy with computational efficiency. Many of the discussed models and metrics such as radius of g5mation [45] are derived from successful protein structure prediction models. As RNA biology is further quantified and the structure prediction field progresses, new techniques to better predict structure may arise. From the models presented, several improvements are evident ... 

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