Strategies for Selection

The systematic variation displayed by the score plots can be used in various ways for designing test sets for experimental studies. Which kind of design should be used will depend on the problem to be treated. 

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Strategies for selective partial alkylation of cyclam have been developed and Ni11 complexes of the variously substituted ligands prepared.1489 In a series of tetra-A-alkylated cyclams, Ni11 incorporation was only observed for smaller substituents such as Me, Et, and Pr, while no... 

Hedhammar, M., Graslund, T., and Hober, S. 2005. Protein engineering strategies for selective protein purification. Chemical Engineering and Technology 28, 1315-1325. 

An alternative strategy for selective intermolecular G-H insertions has been the use of rhodium carbenoid systems that are more stable than the conventional carbenoids derived from ethyl diazoacetate. Garbenoids derived from aryldiazoacetates and vinyldiazoacetates, so-called donor/acceptor-substituted carbenoids, have been found to display a very different reactivity profile compared to the traditional carbenoids.44 A clear example of this effect is the rhodium pivalate-catalyzed G-H insertion into cyclohexane.77 The reaction with ethyl diazoacetate gave the product only in 10% yield, while the parallel reaction with ethyl phenyldiazoacetate gave the product in 94% yield (Equation (10)). In the first case, carbene dimerization was the dominant reaction, while this was not observed with the donor/acceptor-substituted carbenoids. 

Griffeths AD, Duncan AR. Strategies for selection of antibodies by phage display. Curr Opin Biotechnol 1998 9 102-108. 

Sedlak D.L., C.-H. Huang, and K. Pinkston (2004). Strategies for Selecting Pharmaceuticals to Assess Attenuation During Indirect Potable Water Reuse. In K. Kiimmerer (Ed.). Pharmaceuticals in the Environment Sources, Fate, Effects and Risks. Springer, New York, pp. 107-120. 

Ethylenic cation radicals are also capable of rotating around the double bond. At the same time, the main specificity of ethylenic cation radical reduction consists of the high selectivity of the reaction. One-electron oxidation was developed as a strategy for selective and efficient reduction of relatively ionizable functionalities, including conjugated dienes, styrenes, and vinyl sulfides (Mirafzal et al. 1993). Reduction is highly sensitive to substrate ionizability and permits selective reduction of the more ionizable function in a difunctional compound. 

The equivalent circuit corresponding to this resistive network is shown in Fig. 7.8. The current that carries the information about the analyte flows through the path of the lowest resistance. This seemingly trivial circuit can help us to design the best strategy for selectivity of amperometric sensors. 

Another strategy for selective delivery of CA s at cancer cells exploits the intrinsic overexpression of sialic acid in them. Upon incubation of cancer cells with peracetylated N-levulinoylmannosamine the sialoside biosynthetic pathway affords N-levulinoyl sialic acid, the ketone group of which can be a target for an Gd3+ complex of an aminooxy-functionalized DTPA derivative [165]. 

Finding There has not been a coordinated and consistent public-health-based strategy for selecting how chemicals are included in or excluded from biomonitoring studies. There is a need for a consistent rationale for selecting chemicals for study based on exposure and public-health concerns. 

A strategy for selection of solvent systems has been developed and illustrated for 14 anesthetics [38] and 15 steroids [39]. Additional information can also be found in a dated but nevertheless useful review [36]. 

The few experiments available to date about single-molecule chemistry have provided a different view of understanding the complexities behind excitation and relaxation of vibrational in adsorbates. Certainly, more than a tool for technological processing, it will develop concepts and strategies for selectively studying catalytic reactions. 

Mattow J, Siejak F, Hagens K et al (2007) An improved strategy for selective and efficient enrichment of integral plasma membrane proteins of mycobacteria. Proteomics 7 1687-1701... 

Greisman, H. A., and Pabo, C. O. (1997). A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites. Science, 275, 657-661. 

As described for antibody humanization, phage display strategies for selecting new antibodies can also be utilized to evolve existing antibodies. 

Before proceeding with a discussion on the individual modes of separation it is worth reviewing a brief glossary of terms in association with the stationary phase properties. A simple strategy for selection of the stationary phase will naturally follow, in order to help the reader to choose a supplier wisely. 

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