Store-operated calcium channel

Parekh A.B., and Putney J.W., Jr. 2005 Store-operated calcium channels. Physiol Rev 85, 757-810. 

Soboloff J., Spassova M.A., Tang X.D., Hewavitharana T., Xu W., and Gill D.L. 2006 Orail and STIM reconstitute store-operated calcium channel function. J Biol Chem 281, 20661-20665. 

NOs NO synthase PDEs phosphodiesterases sCC soluble gunnylatc cyclase SOCC store-operated calcium channel IOCC voltage-opernled calcium channel ( ) activation (-) inhibition. 

Yoshida, M., Ishikawa, M., Izumi, H., De Santis, R. and Morisawa, M. (2003). Store-operated calcium channel regulates the chemotactic behavior of ascidian sperm. Proc. Natl. Acad. Sci. U.S.A. 100, 149-154. 

Diethylstilbestrol and other non-steroidal estrogens Novel class of store-operated calcium channel modulators... 

Vig M, DeHaven WI, Bird GS, Billingsley JM, Wang H, Rao PE, Hutchings AB, Jouvin MH, Putney JW, Kinet JP Defective mast cell effector functions in mice lacking the CRACMl pore subunit of store-operated calcium release-activated calcium channels. Nat Immunol 2008 9 89-96. 

Striibing C, Krapininsky G, Krapivinsky L, Clapham DE 2001 TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29 645-655 Trepakova ES, Csutora P, Hunton DL, Marchase RB, Cohen RA, Bolotina VM 2000 Calcium influx factor directly activates store-operated cation channels in vascular smooth muscle cells. J Biol Chem 275 26158-26163... 

Kiselyov K, Mignery GA, Zhu MX, Muallem S 1999 The N-terminal domain of the IP3 receptor gates store-operated hTrp3 channels. Mol Cell 4 423-429 Lee HC 2000 NAADP An emerging calcium signaling molecule. J Membr Biol 173 1 -8 Lin S, Fagan KA, Li K-X, Shaul PW, Cooper DMF, Rodman DM 2000 Sustained endothelial nitric-oxide synthase activation requires capacitative Ca2+ entry. J Biol Chem 275 17979-17985... 

Gregory, R.B., Sykiotis, D., and Barritt, G.J. 2003. Evidence that store-operated Ca channels are more effective than intracellular messenger-activated non-selective cation channels in refilling rat hepatocyte intracellular Ca2+ stores. Cell Calcium 34, 241-251. 

It has been proposed that KCAs, such as cromakalim (I), induce their relaxations by opening K tp, the channels closed by ATP, and hyperpolarising the cell membrane. This causes closure of voltage-operated calcium channels and may also affect intracellular calcium stores, the overall result being a relaxation of smooth muscle tone. Other reviews [3,11, 75-79] provide more detailed explanations of the mechanisms involved in KCA-induced relaxations. 

Perez CA, Margolskee RF, Kinnamon SC, Ogura T (2003) Making sense with TRP channels store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium 33 541-549... 

Channels associated with capacitative calcium ion entry have been characterized electrophysiologically. In leukocytes, the current associated with the depletion of intracellular Ca2+ stores is highly Ca2+-selective and, on the basis of noise analysis, is believed to involve minute single channels [16] (see Ch. 6). This is the calcium release-activated calcium current (ICrac)- In other cell types, currents with significantly different properties have been identified, including in some instances store-operated nonse-lective cation channels. These marked electrophysiological distinctions may be indicative of distinct channel types mediating capacitative calcium ion entry in different cell types. 

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