Steroids INDEX

Amino acids, carbohydrates and steroids not found below are in Chapter 4 (see also CAS Registry Numbers Index and General Index). 

Registry Numbers. Annual supplements, with cumulative indexes, have appeared since 1983. A similar work, devoted to organometallic compounds, is the 2nd edition of the Dictionary of Organometallic Compounds , 6 vols. in its 5th supplement, published by Chapman and Hall in 1989. Another, Dictionary of Steroids , 2 vols., 1991, is also published by Chapman and Hall. 

Kuronen P, Volin P, Laitalainen T. 1998. Reversed-phase high-performance liquid chromatographic screening method for serum steroids using retention index and diode-array detection. J Chromatogr B 718(2) 211-224. 

CONTENTS Preface. George W. Gokel. Cryptophanes Receptors for Tetrahedral Molecules, Andre Collett, Jean-Pierre Dutasta and Benedict Lozach. Inclusion Polymerization in Steroidal Canal Complexes, Kiichi Takemoto, Mikiji Miyata. Functionalized Tetraazamacrocycles Ligands with Many Aspects, Thomas A. Kaden. Calixarenes as the Third Supramolecular Host, Seiji Shinkai, Kyushu University, Japan. Fluorescent Chemosensors for Metal and Non-Metal Ions in Aqueous Solutions Based on the Chief Paradigm, Anthony W. Czamik. Index. 

In contrast to anticonvulsants and alcohol, drugs such as bupropion, fluoxetine, fluvoxamine, nefazodone, quinidine, paroxetine, and some antipsychotics can inhibit specific CYP enzymes (7, 11, 36, 37, 41, 42, 43 and 44). Thus, TCAs, certain BZDs, bupropion, some steroids, and antipsychotics can all have their metabolism inhibited by drugs such as fluoxetine. For example, fluoxetine at 20 mg/day produces on average a 500% increase in the levels of coprescribed drugs which are principally dependent on CYP 2D6 for their clearance. That can lead to serious or even life-threatening toxicity if the drug has a narrow therapeutic index and the dose is not adjusted for the change in clearance caused by the coadministration of fluoxetine. 

Estriol (estra-1,3,5(10)-trien-3,16-a,17-8 -triol) is the major estrogen metabolite found in the urine. It is excreted in the form of its conjugate with glucuronic acid. The determination of this steroid as an index of placental function has become one of the most widely used endocrine determinations. As pregnancy progresses, the excretion increases and reaches very high levels near term. In abnormal fetoplacental function, the levels of estriol will fall in some cases. The fall is usually progressive, and, because of this, serial determinations of urinary estriol must be carried out. The drop in estriol can be taken as evidence of placental insufficiency, and close watch by the physician is indicated, as a continued drop may necessitate Cesarean section to save the life of the infant. 

Mrs Patel has a low body mass index (<21) and a history of long-term steroid use. 

I7(x-Methyl-17 -hydroxy-estra-4,9,l l-trien-3-one (Methyltrienolone, N-99). In the course of a steroid total synthesis [293] this compound (Methyltrienolone, N-99) was prepared it was reported [55] to possess 6000% of the androgenic (ventral prostate index), 7500% of the androgenic (seminal vesicles index), and 12,000% of the anabolic (levator ani index) activity of methyltestosterone. Later the anabolic activity was reported [74] to be 30,000% of that of methyltestosterone. As measured by multiple parameters methyltrienolone turned out to be the most hepatotoxic steroid, causing biochemical symptoms of intrahepatic cholestasis [75]. It was also reported [74] to reduce the excretion of 17-ketosteroids and 17-hydroxycorticosteroids and to cause enhancement of the blood coagulation factors V, VII, and X. It also increases the prothrombin content of the plasma [74]. 

Mauser diagrams are very versatile. Every wavelength-dependent property can be used for their construction, e.g., the refractive index or, for optically active photoresponsive molecules, the ellipticity, a property quite sensitive to asymmetric perturbations of the environment. An example is given in Figure 1.6," which shows that on fixation of the azo steroid in PMMA, an optically inactive matrix, the sites are not equivalent. 

---