Sterile water for irrigation

Sulfamylon for 5% topical solution is provided in packets containing 50 g of sterile mafenide acetate to be reconstituted in 1000 mL of sterile water for irrigation or 0.9% sodium chloride irrigation. After mixing, the solution con-... 

Sterile water for irrigation USP Distillation or reverse osmosis Yes 1 L or larger, wide mouth, does not meet particulate matter requirementsfor LVI labeled For Irrigation Only ... 

Comments the USP 28 describes sterile water for irrigation as water for injection sterilized and suitably packaged. It contains no antimicrobial agents or other substances. 

Sterile water for injection and irrigation (excl pour bottles) in containers of 100 ml or more. 

No internalization of E. coli 0157 H7 or Salmonella when introduced into the water for irrigating 3-33-day posttransplanted lettuce plants Surface sterilization using 80% ethanol followed by 0.1% HgCl2 Erickson et al. (2008)... 

Sterile endotoxin free water for irrigation (Travenol). 

Sterile water for Diluent for internal irrigation therapy products. 

For external use it is applied topically to the wound, as a solution containing 100 (o 2.000 NIH uni(s/mL in sodium chloride irrigation or sterile water for injection or as a dry powder. 

Solutions intended for use as large or small volume parenterals, eye-drops, contact lens solutions, peritoneal dialysis solutions, and for irrigation (including non-intravenous water for irrigation use) should be prepared in a room complying with the conditions specified for Grade 2 in Appendix 1. The object should be to prepare a pyrogen-free solution with low microbial and particulate counts, suitable for later sterilization. 

A supply of tap or sterile bottled water for irrigating eyes should be available. Additional items that can be provided include ... 

Ozone can be used to replace chlorine for the sterilization of water. Replacement of chlorine is desirable because chlorination increases the salinity of water. The more salt in the water the less value it has for later use in, for example, irrigation of cropland. When used to sterilize water, chlorine reacts with trace organic compounds to form carcinogenic chlorine compounds such as chloroform. The use of ozone to replace chlorine in water treatment will eliminate chlorination-induced salinity and carcinogenic chlorinated organic compounds. Because of its instability, any residual ozone not consumed in purifying the water rapidly decomposes to ordinary oxygen. 

Fluconazole 200 mg/day for 14 days hastens the time to a negative urine culture as compared with placebo treatment, but 2 weeks after the end of therapy, the frequency of a negative urine culture remains the same with both treatments. Short courses of therapy are not recommended treatment should include removal of catheters and stents whenever possible plus 7 to 14 days of therapy. Bladder irrigation with amphotericin B (50 mg in 500 mL sterile water instilled twice daily into the bladder via a three-way catheter) is only transiently effective. Minimal quantities (<3%) of amphotericin B are absorbed systemically from the bladder. ... 

Water for injections in bulk must comply with the requirements as formulated for Purified water. It must also be produced free of bacterial endotoxins and stored such that it remains free of them. It can be used for parenteral products and irrigations that are terminally sterilised. Water for injections, sterilised, must meet the requirements of sterility (sterility test) and the bacterial endotoxin content must not exceed 0.25 lU per mL. This is used for parenteral products and irrigations that are not terminally sterilised and for dissolving powders for injection immediately before use. 

Because irrigations are used in or on body areas that are usually sterile or have a low degree of contaminatiOTi, there are strict requirements for their production and quality control. In this chapter the use, the design of formulation and preparation method as well as the on site preparation of irrigations will be discussed. With regard to solutions for various types of dialysis, the use of concentrates, the water quality and the requirements for bacterial endotoxins are fully discussed. 

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