Stent-based drug delivery

Stent-based drug delivery as a treatment modality for occlusive coronary artery disease... 

Tesfamarium, B. Local vascular toxicokinetics of stent-based drug delivery. Toxicol. Lett. 168, 93-102 (2007)... 

Mitchel JF McKay RG, Treatment of acute stent thrombosis with local urokinase therapy using catheter-based, drug delivery systems a case report. Cathet Cardiovasc Diagn 1995 34(2) 149-154. 

Another study of stent-based paclitaxel delivery, which also used a degradable polymer [poly(lactide-co-Scaprolactone)] to control the drug-release kinetics, demonstrated sustained reduction in neointimal hyperplasia in the rabbit iliac model (Fg. I I) (56). 

Recently, the concept of controlled corrosion has been proposed as a way to provide implantable devices that can perform a function (e.g., a stent or drug delivery vehicle) and then erode away over time and leave no permanent trace in the body. Some polymeric materials based on this concept have been turned into products, and some magnesium alloys are currently being investigated. 

In parallel to catheter-based delivery, stent-based approaches, such as passive stent coatings (diamond-like carbon, phosphorylcholine, and silicon carbide coatings) and immobilized drug coatings (heparin-coated stents), were evaluated for their ability to inhibit restenosis. Although animal studies demonstrated some promise, none of these technologies were clinically successful for restenosis prevention. The failure of these surface modification technologies further added to the need for the development of DES based on the principles of sustained CDD,... 

Hwang CW, Wu D, Edelman ER, Physiological transport forces govern drug distribution for stent-based delivery. Circulation 2001 104(5) 600-605,... 

A number of randomized clinical trials (RCTs) have investigated stent-based delivery of paclitaxel. These studies utilized a number of different delivery methods, including polymeric sleeves, nonpolymeric drug delivery and from drug-polymer coatings on stents. 

Lewis AL, Vick TA, Collias AC, et al. Phosphorylcholine-based polymer coatings for stent drug delivery. J Mater Sci Mater Med 2001 12 865-870. 

Flugelman MY Weisz A, Koren B, Fischer L, Lewis BS. Stent-based gene therapy from transfection efficiency to biological effect. Sixth International LDD R Local Drug delivery meeting and Cardiovascular Course on Radiation Molecular strategies—Abstract book, (abstr 26), January 28, 2000. 

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