Stearate/stearic acid synthesis

Beilstein Handbook Reference) A13-01781 BRN 1788183 EINECS 203-887-4 Ethyl octadecanoate Ethyl stearate FEMA No, 3490 NSC 8919 Octadecanolc acid, ethyl ester Radia 7185 Stearic acid, ethyl ester. Chemical Intermediate, chemical synthesis lubricant in mineral, cutting, lamination, textile oils, and rust inhibitors textile and leather application also as emollient, plasticizer, solubilizer of active components in cosmetics and pharmaceuticals. Solid mp = 33° bpts = 213-215°, bpio = 199° insoluble in H2O, soluble in EtOH, Et20, CHCI3, very soluble in MezCO, Fina Chemicals. 

Li Q, Du Y-Z et al (2010) Synthesis of Lamivudine stearate and antiviral activity of stearic acid-g-chitosan oligosaccharide polymeric micelles delivery system. Eur J Pharm Sci 41 498-507... 

The synthesis of y-Fe203 nanoparticles is based on the decomposition and subsequent reduction of the intermediate/complex of Fe(0)(stearate) obtained by thermolysis of iron(lll) nitrate in a non-aqueous stearic acid medium. The synthesis procedure was as follows. A homogeneous solution was prepared by gradual addition of a calculated amount of Fe(N03)3. 9H2O to a known amount of molten stearic acid. To have controlled synthesis, the molar ratios of stearic acid to hydrated Fe(lll) nitrate was taken in an optimized ratio. The homogeneous solutions prepared with the above composition were thermolyzed separately at 125 °C until evolution of brown fumes of NO2 ceased. At this stage, the solution became viscous. The viscous mass was allowed to cool and solidify in air. The solidihed mass so obtained was treated with 80 ml of tetrahydrofuran (THF) from which the precipitates were collected by centrifugation. The precipitated mass was then dried at 70 °C in an air oven for several hours. 

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