STATs colony-stimulating factor

Cytokine receptors that couple to the JAK-STAT Pathway decode the signaling though hematopoietic cytokines (erythropoietin, thrombopoietin, colony-stimulating factors), prolactin, growth hormone, the a-, (3- and y- interferons, and a number of immunomodulatory interleukins [3], They form homodimetic or heterodimeric receptor complexes, which after ligandbinding recruit and activate isotypes of Janus kinases (JAKs). Activated JAKs in turn... 

These JAK/STAT-coupled receptors concern the effects of cytokines the growth hormone somatotropin (GH), erythropoietin (EPO), prolactin (PRL), granulocyte-colony-stimulating-factor (G-CSF), granulocyte and macrophage-colony-stimulating-factor (GM-CSF), leptin, thrombopoi-etin, interferons a, 3 and % and interleukins 2, 3,4, 5, 6, 7, 9,10 and 15. 

Activation of STAT Proteins by Colony-Stimulating Factors in... 

TweardyDJ, Wright TM, Ziegler SF, Baumann H, Chakraborty A, White SM, DyerKF, Rubin KA Granulocyte colony-stimulating factor rapidly activates a distinct STAT-like protein in normal myeloid cells. Blood 1995 86 4409-4416. 

Al-Shami A, Mahanna W, Naccache PH Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Selective activation of Jak2, StatS, and Stat5b. J Biol Chem 1998 273 1058-1063. 

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