Starch stearate

Standards for dmg chemicals are pubUshed ia USP—NE. Dmg substances are chemicals that have therapeutic or diagnostic uses, whereas pharmaceutical iagredients provide preservative action, fiavoiing, or hilfillment of a function ia the formulation of dosage-form dmgs. Examples of dmg substances are acetaminophen [103-90-2] ampicillin [69-53-4] aspirin [50-78-2] powdered ipecac, riboflavin [83-88-5] staimous fluoride [7783-47-3] and thyroid. Examples of pharmaceutical iagredients are ethylparaben [120-47-8] lactose [63-42-3] magnesium stearate [557-04-0] sodium hydroxide [1310-73-2] starch [9005-25-8] and vanillin [121-33-5],... 

Ghdants are needed to faciUtate the flow of granulation from the hopper. Lubricants ensure the release of the compressed mass from the punch surfaces and the release/ejection of the tablet from the die. Combinations of siUcas, com starch, talc (qv), magnesium stearate, and high molecular weight poly(ethylene glycols) are used. Most lubricants are hydrophobic and may slow down disintegration and dmg dissolution. 

Cellulose acetate Silica gel Scoured wool Sawdust Rayon waste Fluorspar Tapioca Breakfast food Asbestos fiber Cotton linters Rayon staple Starch Aluminum hydrate Kaolin Cryolite Lead arsenate Cornstarch Cellulose acetate Dye intermediates Calcium carbonate White lead Lithopone Titanium dioxide Magnesium carbonate Aluminum stearate Zinc stearate Lithopone Zinc yellow Calcium carbonate Magnesium carbonate Soap flakes Soda ash Cornstarch Synthetic rubber... 

Fig. 17 Effect of powder bed height, piston height, and compression force on plug ejection force in an instrumented Zanasi LZ-64 automatic capsule-filling machine (pregelatinized starch lubricated with 0.005% magnesium stearate). Note that the first point of each curve is precompression. Piston height (mm) , 15 -jlf, 14 , 13 , 12. Powder bed height (mm) heavy line, 30 light line, 50. (From Ref. 51.)...

DS Desai, BA Rubitski, SA Varia, AW Newman. Physical interactions of magnesium stearate with starch-derived disintegrants and their effects on capsule and tablet dissolution. Int J Pharm 91 217-226, 1993. 

Traditional, dry dusting agents can be rubber insoluble materials such as talc, starch or whiting, or rubber soluble materials such as zinc stearate. A number of dry dusting agents are recognised health hazards and must be handled with care. 

It is a yellow solid with a solubility in water of 0.007 mg/mL. The Tykerb tablet contains 405 mg of the active ingredient, and the inactives are magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate. 

Dusting Powders are sprinkled onto the intact skin and consist of talc, magnesium stearate, silicon dioxide (silica), or starch. They adhere to the skin, forming a low-friction film that attenuates mechanical irritation. Powders exert a drying (evaporative) effect. 

Components with a fixed concentration were Primojel (4%), oxazepam (4%), magnesium stearate (1%) and Aerosil 200R (0.2%). The components with a variable concentration were a-lactose, 6-lactose and rice starch. The concentrations of these components sum up to 90,8% of the total tablet weight, their individual concentrations can be obtained from the experimental design listed in Table 4.3 where the listed values of Xj-Xj are fractions of the total amount of 90.8% for these three components. 

The used tablet ingredients were a-lactose monohydrate (Ph.Eur grade, 100 mesh), rice starch (Ph.Eur. grade) and magnesium stearate (Ph.Eur. grade). Before use the magnesium stearate was sieved through a 210 im sieve. Prior to use, the materials were stored at 20 1 °C and 45 5% relative humidity (RH) for at least one week. 

Tablets of 250 mg with starch concentrations of 5%, 15% and 25% w/w respectively, were prepared. Starch and lactose were mixed for 15 minutes in a Turbula mixer at a rotation speed of 90 rpm.. Magnesium stearate (0.5% w/w) was added and mixing was continued for 2 minutes. The tablets were prepared on a single punch tabletting machine, using 9 mm flat punches. From each mixture tablets were produced at three compression load levels 157,314,472 MPa.

Metallic Stearate Starch Adipic Acid Fiber Coal Filter Cake... 

Metal Stearates Spent 1 Grains Sewageb Sludge Starches Polystyrene Beads... 

Compacting of specific materials can be facilitated with certain kinds of additives. Binders are additives that confer strength to the agglomerates, and lubricants reduce friction during the operation. Some additives may function both ways. A few of the hundreds of binders that have been tried or proposed are listed in Table 12.12. Lubricants include the liquids water, glycerine, and lubricating oils and typical solids are waxes, stearic acid, metallic stearates, starch, and talc. 

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