Starch capsules

Stepto (1997) focused on the injection molding of potato starch including the basis of the process. In addition, the rheological behavior of starch/water melts during the refill part of the injection molding cycle was analyzed quantitatively to give apparent melt viscosities. Finally, the mechanical properties of molded starch materials and the dmg-delivery behavior of starch capsules were also discussed. 

V. Vilivalam, L. L. Ilium, K. K. Iqbal, Starch capsules an alternative system for oral drug delivery, Pharm Sci Technol Today 3(2) 64-69 (2000). 

B. Brogmann, K. Lehmann, Stability of enteric gelatin and starch capsules with aqueous dispersions of methacrylic acid copolymers AAPS Annual Congress, San Diego, 1994. 

The crosslinking of starch at the droplet interface in inverse miniemulsion leads to the formation of hydrogels. The formulation process for the preparation of crosslinked starch capsules in inverse miniemulsion is schematically shown in Fig. 10. The influence of different parameters such as the amount of starch, surfactant P(E/B-fe-EO), and crosslinker (2,4-toluene diisocyanate, TDI) on the capsule size and stability of the system were studied. The obtained capsules were in a size range of 320-920 nm. Higher amounts of starch and surfactant result in a smaller capsule size. The TEM images of crosslinked starch capsules prepared with different amount of crosslinker (TDI) are presented in Fig. 11. The nanocapsules can be employed as nanocontainers for the encapsulation of dsDNA molecules with different lengths [114] and for the encapsulation of magnetite nanoparticles. 

Fig. 10 Preparation of crosslinked starch capsules in an inverse miniemulsion...

Baier G, Musyanovych A, Dass M, Theisinger S, Landfester K (2010) Crosslinked starch capsules prepared in inverse miniemulsion as nanoreactors for dsDNA and polymerase chain reaction. Biomacromolecules 11 960-968... 

P. Watts, A. Smith. TARGIT technology Coated starch capsules for site-specific drug delivery into the lower gastrointestinal tract. Expert Opin Drug Deliv. 2 (1) 159-167, 2005. 

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