Starch blockers

LiENERi E, DONATUCCi DA, TARCZA J c (1984) Starch blockers apotential source oftrypsin inhibitors and lectins. Am J Clin Nutr. 39 196-200. 

UMOREN J, KIES c (1992) Commercial soybean starch blocker consmnption impact on weight gain and on copper, lead and zinc status of rats. Plant Foods Hum Nutr. 42 135-42. 

Starch blocker A trivial name for the class of drugs (mainly intestinal a-amylase inhibitors) that block dietary conversion of polysaccharides and sucrose to monosaccharides. Such drugs are used in diabetes management, status epilepticus See epilepsy, steady-state In relation to drug metabolism, when the rate of drug intake equals the rate of drug elimination, a steady-state concentration is achieved, stenosis Narrowing or contraction of a duct. 

The failure of the starch blockers to decrease starch hydrolysis may be due to several factors. It is possible that much of the inhibitor, a glycoprotein (Marshall and Lauda, 1975), is destroyed in the stomach by pepsin or acid. Once in the small intestine, the pH would be sufficiently far from the optimum for... 

Bo-Linn, G., Santa Ana, C., Morawski, S., and Fordstran, J., 1982, Starch blockers - their effect on calorie absorption from a high-starch meal. New Engl. J. Med., 307 1413-1416. 

Type II diabetes Stimulating the release of insulin from the pancreas. ATP-dependent K-channel blocker Calcium hydrogen phosphate, MCC, maize starch, polacrilin, potassium, povidone, glycerol (85%), magnesium stearate, meglumine, poloxamer Novo Nordisk... 

Tikosyn Dofetilide 125, 250, 500 (jig Capsule Maintenance of normal sinus rhythm and conversion of atrial fibrillation/ flutter Cardiac ion channel blocker/ antiarrhythmic drug MCC, corn starch, silicon dioxide, magnesium stearate Pfizer... 

Sunlight blockers such as clays, starches or carbon may be preferable because they are less expensive, environmentally innocuous and/or biodegradable (20, 38). 

A number of compounds have been marketed as carbohydrate blockers , which are supposed to act by inhibiting amylase (section 4.2.2.1), and so reducing the digestion of starch. There is no evidence that they are effective, and none has been licensed for pharmaceutical use. 

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