Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Tikosyn - Dofetilide

Tikosyn Dofetilide 125, 250, 500 (jig Capsule Maintenance of normal sinus rhythm and conversion of atrial fibrillation/ flutter Cardiac ion channel blocker/ antiarrhythmic drug MCC, corn starch, silicon dioxide, magnesium stearate Pfizer... [Pg.15]

Tikosyn (Dofetilide), Pfizer Labs, US Prescribing information, March 2004. [Pg.255]

Tikosyn (Dofetilide). Pfizer US Pharmaceuticals. Product monograph, March 2002. Available at htti) /Avww.tikos3m.com/pdf prodmonograph.pdf (accessed 17/08/07). [Pg.255]

Dofetilide (Tikosyn) Esmolol (Brevibloc) Flecainide (Tambocor) Ibutilide (Corvert) Mexiletine (Mexitil) Procainamide (Pronestyl,... [Pg.40]

Dofetilide (Tikosyn) [Antiarrhythmic] warning To minimize the risk of induced arrhythmia, hospitalize for minimum of 3 d to provide calculations... [Pg.138]

Dofetilide (Tikosyn) is a pure class III drug. It prolongs the cardiac action potential and the refractory period by selectively inhibiting the rapid component of the delayed rectifier potassium current (IKr). [Pg.189]

TIKOSYN (Pfizer) (dofetilide) capsules December 1999 labeling... [Pg.267]

Inhibitors of the CYP3A4 isoenzyme could increase systemic dofetilide exposure. Inhibitors of this isoenzyme (e.g., macrolide antibiotics, azole antifungal agents, protease inhibitors, serotonin reuptake inhibitors, amiodarone, cannabinoids, diltiazem, grapefruit juice, nefazadone, norfloxacin, quinine, and zafirlukast) should be cautiously coadministered with TIKOSYN, because they can potentially increase dofetilide levels... [Pg.267]

The chapter ends with a complete synthesis of an important new drug. Cardiac arrhythmia (erratic and inefficient heart action) is a major problem in the modern world causing poor lifestyle (exhaustion) and death by blood clots. A new drug dofetilide (Tikosyn ) is being introduced by Pfizer to treat this problem. It works by blocking the passage of potassium ions out of heart muscle and so delays the onset of an irregular beat until the next normal beat takes over. [Pg.658]

Class III antiarrhythimic agents sotalol (Betapace) dofetilide (Tikosyn) ibutilide (Covert)... [Pg.444]

See other pages where Tikosyn - Dofetilide is mentioned: [Pg.682]    [Pg.682]    [Pg.370]    [Pg.372]    [Pg.17]    [Pg.20]    [Pg.297]    [Pg.325]    [Pg.346]    [Pg.658]    [Pg.649]    [Pg.209]    [Pg.209]    [Pg.370]    [Pg.372]    [Pg.1093]    [Pg.274]   


SEARCH



© 2024 chempedia.info