Starburst synthesis

Tomalia, D.A. et al. Dendritic macromolecules—Synthesis of starburst dendrimers, Macromolecules, 19, 2466-2468, 1986. 

In a more recent paper, Roy et al. reported on the synthesis and biological pro -perties of mannosylated Starburst dendrimers [46]. In addition to the presence of good biological properties in ligand- and inhibitor-tests, these dendrimers were shown to constitute novel biochromatography materials of high affinity for the rapid and easy isolation and purification of carbohydratebinding proteins from crude mixtures. 

Tomalia, D. A. Genealogically Directed Synthesis Starburst/Cascade Dendrimers and Hyper-branched Structures. 165 (1993). 

D. Page and R. Roy, Synthesis and biological properties of mannosylated starburst Poly(amidoamine) dendrimers, Bioconjug. Chem., 8 (1997) 714—723. 

D. Zanini and R. Roy, Practical synthesis of starburst PAMAM a-thiosialoden-drimers for probing multivalent carbohydrate-lectin binding properties, J. Org. Chem., 63 (1998) 3486-3491. 

Wilbur, S.D., Pathare, P.M., Hamlin, D.K., Buhler, K.R., and Vessella, R.L. (1998) Biotin reagents for antibody pretargeting. 3. Synthesis, radioiodination, and evaluation of biotinylated starburst dendrim-ers. Bioconjugate Chem. 9, 813-825. 

Tomalia, D. A. and Dvornic, P. R. Dendritic polymers, divergent synthesis (starburst polyamidoamine dendrimers) , in Salamone, J. C. (ed.), Polymeric Materials Encyclopedia, Vol. 3, CRC Press, Boca Raton, FL, 1996, pp. 1814-1830. 

Tomalia, D. A. and Durst, H. D. Geneologically directed synthesis Starburst/ Cascade dendrimers and hyperbranched structures , Topics Curr. Chem., 165, 193— 313(1993). 

This lecture exposed these rather revolutionary concepts to an elite scientific community in Europe. Secondly, an invitation by Dr. P. Golitz (Editor, Angew. Chem.) to publish an important review [20] entitled Starburst dendrimers molecular-level control of size, shape, surface chemistry, topology and flexibility from atoms to macroscopic matter provided broad exposure to the basic concepts underlying dendrimer chemistry. Finally, important contributions by key researchers significantly expanded the realm of dendrimer chemistry with the convergent synthesis approach of Frechet and Elawker [37] (Figure 4), as well as the systematic and critical photophysical characterization of Turro et al [38],... 

A very productive strategy for the synthesis of glass-forming materials is the use of highly branched rigid structures. As a suitable center for starburst molecules with a threefold symmetry, triarylamine or benzene are used most frequently. Due to the large number of starburst molecules described in the literature, we divide this class into two subgroups, compounds based on the triarylamine and the benzene centers. 

Up to now, the equilibrium structure of flexible dendrimers in solution has been treated in several exhaustive theoretical studies [6-13]. Shortly after the first experimental reports on the synthesis of dendrimers their spatial structure was considered by de Gennes and Hervet [6]. These authors derived a density profile which has a minimum at the center of the starburst and increased monotonically to the outer edge. It must be noted that de Gennes and Hervet assumed that all subsequent bonds point to the periphery of the molecule. A structure complying with this assumption may be given by the fully aromatic dendrimers as displayed in Fig. 2. In consequence, the dense-shell picture" deriving from this theory is built into the model. It should not be regarded as its result. 

Tomalia DA, Baker H, Dewald J, Hall M, Kallos G, Martin S, Roeck J, Ryder J, Smith P. Dendritic macromolecules synthesis of starburst dendrimers. Macromolecules 1986 19 2466-2468. 

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