Starburst activity

Singh, P. (1998) Terminal groups in starburst dendrimers Activation and reactions with proteins. Bioconjugate Chem. 9, 54-63. 

Starburst 99 (Leitherer et al. 1999, 2001) gives synthetic spectra for actively star-forming galaxies assuming a selection of different ages, metallicities and initial mass functions. 

Our results have shown that the use of STARBURST dendrimers for the covalent coupling of the molecules of biological interest can lead to a reproduc-ibly performing product with very little impact on the biological activity of the immobilized protein. By careful optimization of the reaction parameters, it has... 

Antibodies have been coupled1271 to starburst (PAMAM) dendrimers these reagents offer an attractive approach to the development of immunoassays. These dendritic reagents are stable and retain full immunological activity - both in solution as well as when bound to a solid substrate their analytical sensitivity is equal to or is better than that of the established methods. The dendritic approach to radial partition immunoassays has been shown to possess the best traits of both homogeneous and heterogeneous immunoassay formats. 

Examination of the genealogical mimicry involved in the construction and synthesis of Starburst/cascade dendrimers places this activity at the interface between chemistry and biology. Essentially all genealogical phenomena in biological systems involve and evolve around two generic classes of compositions, namely (a) nucleic acids and (b) proteins. The nucleic acids, DNA and RNA are estimated to be over three billion years old by radioactive carbon dating (see Ref. 206) (see Fig. 45). 

In addition to the repeat unit sequence, another area of current interest in polymer structural control (Fig. 1) may be the spatial or three-dimensional shapes of macromolecules. In fact, the recent development of star [181-184] and graft [185] polymers, as well as starburst dendrimers [126], arborols [186,187], and related multibranched or multiarmed polymers of unique and controlled topology, has been eliciting active interest among polymer scientists. In this section, let us consider the following macromolecules of unique topology for which living cationic polymerizations offers convenient synthetic methods that differ from the stepwise syntheses (polycondensation and polyaddition) [126,186,187]. 

Previously, dendrimers were used as organic matrices for the synthesis of a variety of inorganic nanomaterials and inorganic-organic composites [36, 159]. Dendrimers with different generations have been discovered as active additives for the controlled crystallization of CaCOs [159,160]. It has been demonstrated that anionic starburst dendrimers can stabilize spherical va-terite particles for up to a week with controllable particle size in the range of 2.3-5.5nm in dependence on the dendrimer generation number [161]. In addition, the combination of poly(propylene imine) dendrimers with oc-... 

The procedure details and outcomes reported in this chapter represent our experience with the RITA system (RITA Medical Systems, Mountain View, Calif., USA) and the RITA StarBurst XL electrode. The electrode deployment is adjustable for the creation of ablation from 3 to 5 cm. This device has nine active electrodes (five with thermocouples), and an active trocar tip. We have opted for this system because of its expandable hooks, which cling to the tissue and thus are not subject to breathing-related dislocation. The system is user-friendly, and data from the generator (power, impedance, temperature, time, etc.) can be collected and displayed on a computer. 

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