Staphylococcus aureus expression regulation

Fan, F. et al. 2001. Regulated ectopic expression and allelic-replacement mutagenesis as a method for gene essentiality testing in Staphylococcus aureus. Plasmid46, 71-75. 

Zhang, L. et al. 2000. Regulated gene expression in Staphylococcus aureus for identifying conditional lethal phenotypes and antibiotic mode of action. Gene 255, 297-305. 

Ji, G., and Silver, S. (1992a). Regulation and expression of the arsenic resistance operon from Staphylococcus aureus plasmid pI258. J. Bacteriol. 174, 3684-3694. 

Morfeldt Cl, Janzon L, Arvidson S, LSfdahl S (1988) Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus. Mol Gen Genet. 211 1601-1607... 

Schulthess B, Bloes DA, Francois P, Girard M, Schrenzel J, Bischofif M, Beiger-Baechi B. The extracellular nuclease, lipase, and protease expression in Staphylococcus aureus. JBacteriol. 2011 193 4954-62. 

Resistance to the toxic effects of mercury is quite commonly found in bacteria (Silver and Walderhaug 1992 Misra 1992). Since most bacteria are rarely exposed to toxic levels of mercury, the resistance mechanism is inducible and is frequently found on plasmids and/or transposons. Many of the multi-antibiotic resistance plasmids that are frequently found in clinical collections have determinants of mercury resistance as well. Furthermore, mercury resistance is a consistent component of the chromosomal resistance determinant of MRS A (methicillin-resistant Staphylococcus aureus), a current clinical problem and one with no apparent connection to the use of mercurials. If the mercury resistance system is present, the expression of the detoxifying activities is tightly regulated and turned on only when needed. The MerR regulatory protein turns on mRNA synthesis by a positive activator mechanism (for primary references, see Silver and Walderhaug 1992 Misra 1992). 

Bronner, S. Jehl, F. Peter, J.-D. Ploy, M.-C. Renault, C. Arvis, P. Monteil, H. Prevost, G. Moxi-floxacin efficacy and vitreous penetration in a rabbit model of Staphylococcus aureus endophthalmitis and effect on gene expression of leucotoxins and virulence regulator factors, Antimicrob.Agents Chemother.,2W)3,47, 1621-1629. 

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