Stage-appropriate analysis model

TABLE 14.1 The Stage-Appropriate Analysis Model Applied for Hit-to-Lead and Lead... 

The biological relevance and feasibility of the results obtained with this connec-tionist approach are confirmed in a second stage of analysis with computer simulations of realistic, spiking neuron models presented in section 1.3. I will indicate the details of the models when they are introduced and will refer to previously published work where appropriate. 

Classical EIS data analysis consists of two stages (i) elucidation of an appropriate physical model of the system and (ii) fitting of EIS data to the model (Equivalent Electric Circuit,... 

For the majority of existing seismically vulnerable stmctures, it is wished that, after a reasonable stmctural intervention and under a critical earthquake, only repairable damage may occur or (at least) collapse will be avoided. Thus, it is expected that several regions of the structure will be found in a post-yield stage. This means that the most appropriate analysis should be nonlinear. The use of such analytical models is much more needed in the case of intervention than in the case of new structures. And to this end, typical hysteretic behavior of structural elements should be known. 

In addition, the variance of impedance measurements depends strongly on frequency, and this variation needs to be addressed by the regression strategies employed. An assumed dependence of the variance of the impedance measurement on impedance values was employed in early stages of regression analysis, and this gave rise to some controversy over what assumed error structure was most appropriate. An experimental approach using measurement models, described in Chapter 21, was later developed, which eliminated the need for assumed error structures. 

Specifying a relevant network of reactions and regulatory interactions requires at least qualitative kinetic information, but this specification establishes only the skeleton of the model. While certain qualitative results that are independent of specific parameter values can be obtained by mathematical analysis at this stage, more detailed quantitative predictions require that appropriate rate laws be specified for the reactions of the system. 

The quantum theory of reactive scattering and the calculation of potential energy surfaces are reviewed elsewhere in this volume. Here attention will be confined to two recent theoretical models which are both simple and should be widely applicable. Thus, they are appropriate to the analysis of experimental data at an early stage, in order to help discern the nature of the reaction dynamics. 

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