Receptor sperm

Florman, H. M., and Wassarman, P. M. (1985). O-linked oligosacharides of mouse egg ZP3 account for its sperm receptor activity. Cell 41 313-324. 

Litscher, E.S. and Wassarman, P.M. (1996). Recombinant hamster sperm receptors that exhibit species-specific binding to sperm. Zygote 4 229-236. 

Liu, C., Litscher, E. S., and Wassarman, P.M. (1995). Transgenic mice with reduced numbers of functional sperm receptors on their eggs reproduce normally. Mol. Biol. Cell. 6 577-585. 

Several signals are generated following ZP3 binding to a sperm receptor. Intracellular Ca - and pH increase, and cAMP rises are also reported. The mechanisms by which these second messengers are generated will be considered here. 

Bleil, J.D. and Wassarman, P.M. (1988). Galactose at the nonreducing terminus of O-linked oligosaccharides of mouse egg zona pellucida glycoprotein ZP3 is essential for the glycoprotein s sperm receptor activity. Proc. Natl. Acad. Sci. 85 6778-6782. 

Leyton, L., and Saling, P.M. (1989b). Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction. J. Cell Biol. 705 2163-2168. 

Rosiere, T.K. and Wassarman, P.M. (1992). Identification of a region of mouse zona pellueida glycoprotein mZP3 that possesses sperm receptor activity. Dev. Biol. 754 309-319. 

Wassarman, P.M. (1990). Profile of a mammalian sperm receptor. Development 708 1-17. 

Comparison of the Potency of Cannabinergic Ligands in Displacing [ H]CP55940 from Sperm Receptors with Their Potency in Blocking the Egg-Jelly-Stimulated Acrosome Reaction in the Sea Urchin Strongylocentrotus Purpuratus... 

Scarped SL, Sanchez ML, Cabada MO. 2008. Cellular origin of the Bufo arenarum sperm receptor gp75, a ZP2 family member its proteolysis after fertilization. Biol Cell 100(4) 219-230. 

Tian J, Gong H, Lennarz WJ. 1999. Xenopus laevis sperm receptor gp69/64 glycoprotein is a homolog of the mammalian sperm receptor ZP2. Proc Natl Acad Sci U S A 96(3) 829-834. 

Ascidian sperm glycosylphosphatidylinositol-anchored CRISP-like protein as a binding partner for an allorecognizable sperm receptor on the vitelline coat. J Biol Chem 283(31) 21725-21733. 

Wassarman PM, Litscher ES. 2001. Multiple functions of mouse zona pellucida glycoprotein mZP3, the sperm receptor. Ital J Anat Embryol 106(2 Suppl 2) 21-32. 

Based on the above findings, it is proposed that the function of cleavage of the N-terminus of the sperm receptor is to abolish sperm-egg interaction after egg activation (see [23], for additional evidence). Analysis of the deduced amino acid se-... 

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