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Specificity exploratory applications

CE has many separation modes that are beneficial to protein impurity analysis. Within the many thousands of potential protein impurities in a recombinant product there will be several that have only minor physicochemical differences from the drug product. The application of different CE modes can potentially resolve these impurities. CE methods can be divided into four principle modes that are applicable to recombinant protein impurity analysis capillary zone electrophoresis, capillary isoelectric focusing, capillary gel electrophoresis, and micellar electrokinetic capillary chromatography. Each mode will be discussed briefly. Since the technology is so young and still very exploratory, CE methods are developed empirically for specific separations. It is difficult to provide standard protocols for CE impurity analysis. Instead, protocols that can be used as a starting point for impurity analysis will be provided as well as the citation of examples of impurity analyses from the literature to provide additional sources of protocols for interested readers. [Pg.43]

In this chapter we have chosen not to focus on specific examples of smart textiles application in order to avoid narrowing the field of smart implantable fibrous medical devices to a few innovative textile properties. Contrariwise, fiber characteristics are pointed out to show that all of them, in a prospective designing approach, could achieve smart features in the implantable device area. However, we are limited in exploratory areas using new materials because a decline is needed to be certain that a material is accepted by the body. Given the diversity of appreciation of smart appearance, as well as the implantable medical device aspect, we have focused on the biocompatibility and biointegration of substitutes in their environment. This theme therefore needs to be complemented by other approaches such as the concepts of smart attitude and implantable device as related in Fig. 13.1. [Pg.301]


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See also in sourсe #XX -- [ Pg.145 , Pg.147 ]




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Specific applications

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