Spatiotemporal regulation

Pitsi and Octave (196) demonstrated that the expression of PSl, which binds C99, not only increases the production of ABP but also increases the intracellular levels of C99 to the same extent. A functional inhibitor of y-secretase does not alter the ability of PSl to increase the intracellular levels of C99, suggesting that the binding of PSl to C99 does not necessarily lead to its immediate cleavage by y-secretase, which could be a spatiotemporally regulated or an induced event (196). Missense mutations in PSl and PS2 shift the ratio of ABPl-40/ABPl-42 to favor ABPl-42. A possible explanation of this outcome is that mutant PS alters the specificity of y-secretase to favor production of ABPl-42 at the expense of ABPl-40. 

Honda, K., Ohba, Y., Yanai, H., Negishi, H., Mizutani, T., Takaoka, A., Taya, C., et al., Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434 (2005) 1035-1040. 

Vohnat, V Pouyssegur, J. (2001). Spatiotemporal regulation of the p42/p44 MARK pathway. Biology of the Cell, 93, 71-79. 

Adaptor proteins are multi-domain proteins (Fig. 1) that interact with components of signaling pathways [1]. As a consequence of these interactions, adaptor proteins are able to regulate signaling events within the cell, providing spatiotemporal control and specificity, and influencing how a cell responds to a particular stimulus. 

Sohal, V. S., Huntsman, M. M and Huguenard, J. R. (2000) Reciprocal inhibitory connections regulate the spatiotemporal properties of intrathalamic oscillations../. Neurosci. 20, 1735-1745. 

J. Dubrulle, M. J. McGrew, and O. Pourquie, FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation. Cell 106,219— 232 (2001). 

Complementary observations of the aftereffects of enzymatic hydrolysis on the graft copolymers show spatiotemporally controlled degradation, leading to a new method for fine surface abrasion as well as for degradation-rate regulation of polymeric materials. 

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