Sorbitol dosage

If a liquid dosage form of a medication exists, it would seem rational to use this dosage form for administration through a feeding tube. Although such a decision may decrease the potential for tube clogging, it may in some instances decrease tolerability of the medication administration. Sorbitol is an excipient found in many liquid medications in amounts sufficient to cause diarrhea. If diarrhea secondary to sorbitol in a liquid medication is suspected in a patient on EN, contact with the manufacturer to ascertain sorbitol content may be necessary. 

Sorbitol is a polyhydric alcohol, with a high caloric content. In a survey of 129 oral liquid dosage forms stocked at a large university teaching hospital, 42% contained sorbitol [66]. The sorbitol concentration in the identified products varied from 3.5 to 72% w/v (0.175-3.6 g/mL). 

Solutions. For oral solutions, elixirs, syrups, tinctures, or other solubilized forms, in vivo BA and/or BE can be waived [21 CFR 320.22(b) (3) (i)]. Generally, in vivo BE studies are waived for solutions on the assumptions that release of the drug substance from the drug product is self-evident and that the solutions do not contain any excipient that significantly affects drug absorption [21 CFR 320.22(b)(3) (iii) ]. However, there are certain excipients, such as sorbitol or mannitol, that can reduce the BA of drugs with low intestinal permeability in amounts sometimes used in oral liquid dosage forms. 

Certain materials such as sorbitol or hydrophilic polymers are added to solution dosage forms to improve pourability and palatability by increasing viscosity. This higher viscosity may slow gastric emptying and absorption. 

Chem. Descrip. Sorbitol CAS 50-70-4 EINECS/ELINCS 200-061-5 Uses Humectant, plasticizer, softener, and lubricant for personal care prods., adhesives, leather, and paper coatings humectant, plasticizer, softener, lubricant, sweetener for oral hygiene prods, such as dentifrices, mouthwashes, oral dosage pharmaceuticals Features Adds sweet taste and pleasant mouthfeel to orals Properties Clear colorless sol n. water-sol. sp.gr. 1.29-1.32 ref. index 1.455-1.470 pH neutral Liponic76-NC [Lipo]... 

For approximately 80 raw materials the Ph. Eur. has set limits for endotoxin levels if they are intended for parenteral dosage forms. These include among others dextran, sorbitol and mannitol, sodium chloride, trometamol, water for injections. 

In contrast to other authors, we have been unable to find severe adverse reactions by these substances. The rise in lactate concentration and the increase in the lactate/pyruvate ratio are common metabolic consequences of carbohydrate metabolism. The increase in uric acid and serum bilirubin concentrations has been reported as adverse reactions. However, the increase in uric acid concentration was also observed after oral sucrose intake. Rapid intravenous infusions of fructose, sorbitol and xylitol at high dosages of 1.5 g per kg were followed by an increase in the serum bilirubin concentration. Glucose, however, caused the same... 

Oral Solid Dosage Forms (OSDF) and Pharma Excipients Market for Polymers (MCC, HPMC, CMC, Ethyl Cellulose, Povidone and Others), Alcohols (Glycerin, Sorbitol, Mannitol, Propylene Glycol), Minerals (Clay, Silicon Dioxide, Titanium Dioxide) and Sugars (Lactose, Sucrose) - Global Industry Analysis, Size, Share, Trends, Analysis, Growth and Forecast, 2012 - 2018,2013. 

The surface acidities of a wide variety of excipients used in solid dosage forms have been determined using absorption indicators. A wide number of fillers, binders, disintegrants, and lubricants were found to exhibit Hq values in the range of 3-4, and only a few excipients exhibited Hq values larger than this. In fact, potassium bicarbonate Hq = 8.Q5), sodium bicarbonate (Ho = 8.27), and sodium carbonate Hq = 8.58) were found to be the only excipients studied, whose surfaces exhibited basic properties. As shown in Figure 2, bromcresol green exists primarily in its acid form when adsorbed onto anhydrous dicalcium phosphate, primarily in its basic form when adsorbed onto sodium bicarbonate, but is distributed between its acidic and basic form when adsorbed onto sorbitol. 

---