Somogyi effect

Somogyi effect, including rebound hyperglycemia with chronically excessive insulin dosages systemicallergic reaction, marked by rash, angioedema, and anaphylaxis lipodystrophy or depression at injection site due to breakdown of adipose tissue lipo-hypertrophy or accumulation of subcutaneous tissue at injection site due to inadequate site rotation Rare... 

Excessive dose of insulin leads to overeating and obesity it also leads to hypoglycaemia (especially nocturnal), that may be followed by reboimd morning hyperglycaemia that is mistakenly treated by increased insulin, thus establishing a vicious cycle (Somogyi effect). 

Infrequent Somogyi effect (rebound hyperglycemia) with chronically excessive insulin doses. Systemic allergic reaction (rash, angioedema, anaphylaxis), lipodystrophy (depression at injection site due to breakdown of adipose tissue), lipohypertrophy (accumulation of SC tissue at injection... 

Assistant Professor Department of Pediatrics Children s Nutrition Research Center Baylor College of Medicine Houston, Texas Anorexia Nervosa Somogyi Effect Type II Diabetes... 

Liachenko S, Tang P, Somogyi GT, Xu Y. (1999). Concentration-dependent isoflurane effects on depolarization-evoked glutamate and GABA outflows from mouse brain slices. Br J Pharmacol. 

Dongre, A.R. Somogyi, A. Wysocki, V.H. SID an Effective Tool to Probe Structure, Energetics and Fragmentation Mecharrisrrrs of Protonated Peptides. J. Mass Spectrom. 1996, 31, 339-350. 

Somogyi, G. Effect of ozone atmosphere on the detecting properties of plastic track recorders. Radiat. Eff. 16 233-243, 1972. 

Doverty M, Somogyi AA, White JM, Bochner F, Beare CH, Menelaou A, Ling W. Methadone maintenance patients are cross-tolerant to the antinociceptive effects of morphine. Pain 2001 93(2) 155-63. 

Possible mechanisms responsible for this stereoselective renal clearance of pindolol appear to be stereoselective renal metabolism or stereoselective renal secretion (stereoselective binding to plasma proteins was not observed). Recently, Somogyi et al. investigated the effect of coadministration of dmetidine on the renal clearance of the two enantiomers of pindolol (58). Cimetidine significantly reduced the renal clearance of both enantiomers, but reduced the renal clearance of the R enantiomer by a greater extent than the S enantiomer. These data are consistent with the stereoselective renal elimination mechanism for pindolol, with the S enantiomer being preferentially cleared. 

Somogyi AA, Shanks CA, Triggs EJ. The effect of renal failure on the disposition and neuromuscular blocking action of pancuronium bromide. Eur J Clin Pharmacol 1977 12(l) 23-9. 

Knoll J, Vizi ES, Somogyi G (1968) Phenylisopropylmethylpropinylamine (E-250), a monoamine oxidase inhibitor antagonizing the effects of tyramine. Arzneimittelf 18 109-112... 

AR Dongre, A Somogyi, VH Wysocki. Surface-induced dissociation an effective tool to probe structure, energetics and fragmentation mechanisms of pro-tonated peptides. J Mass Spectrom 31 339—350, 1996. 

A Somogyi, VH Wysocki, I Mayer. The effect of protonation site on bond stmgths in simple peptides Application of ab initio and modified neglect of differential over-... 

Nyitral, M., Hild, G., Lakos, Zs and Somogyi, B, 1998, Effect of Ca -Mg exchange on the flexibility and/or conformation of the small domain in monomeric actin. Biophysical Journal 74, 2474-2481. 

Eichelbaum, M. Birkel, P. Grube, E. Gutgemann, U. Somogyi, A. Effects of verapamil on P-R-intervals in relation to verapamil plasma levels following single I.V. and oral administration and during chronic treatment. Klin. Wochenschr. 1980, 58, 919-925. 

Somogyi AA, Bochner F, Keal JA, Rolan PE, Smith M. Effect of food on enoxacin absccp-tion. Antimicrob Agents Chewio er(1987) 31,638-9. 

There are few references in the literature to the inhibition of oxidase enzymes by naturally occurring substances. The presence of a substance in many fruits and vegetables which effectively inhibits the oxidation of ascorbic acid, whether this is brought about by ascorbic oxidase, poly-phenolase, peroxidase, or by inorganic Cu, has been reported by Somogyi (1944), but the nature of this substance or substances was not identified. Damodaran and Nair (1936) isolated a tannin from the Indian gooseberry (Phyllanthus emblica) which inhibited the oxidation of ascorbic acid in the press juice. Since the protective effect of this substance could be overridden by the addition of Cu, they concluded that its action depended on the suppression of metal catalysis. 

A systematic comparison of experimentally obtained spectral data with modeling results based on Monte Carlo simulations can pinpoint and show ways to correct for all these effects and eventually bring the measurement accuracy in line with the accuracy of the physical parameters characterizing the X-ray - sample interaction processes. Ultimately, the quality of results that can be reached with this method depends on the accuracy of available physical parameters, mainly the cross sections for X-ray interactions that are, in the most favorable circumstances, 5% for K radiation of elements between Z= 20 and 50,10 - 15% for L radiation between Z= 50 and 80 (Elam et al. 2002 Somogyi et al. 2000). 

Although the measurement of electricity through its chemical effects began quite early, the reverse of this process received little attention. The first major development occurred in 1938, when the Hungarian workers L. Szebelledy and Z. Somogyi described the titration of, for example, HCl with electrogenerated hydroxyl ion ( 0). The technique, coulometric titration, was rapidly extended, largely by American workers (41). 

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