Somatotrope

Growth hormone, also called somatotropic hormone, is secreted by the anterior pituitary. This hormone regulates the growth of the individual until somewhere around early adulthood or the time when the person no longer gains height. 

Somatotrope Growth hormone producing cells in the anterior pituitary. 

B16. van den Berghe, G., de Zegher, F Veldhuis, J. D., Wouters, P Awouters, M Verbruggen, W., Schetz, M Verwaest, C Lauwers, R, Bouillon, R and Bowers, C. Y., The somatotropic axis in critical illness Effect of continous growth hormone (GH)-releasing hormone and GH-re-leasing peptide-2 infusion. J. Clin. Endocrinol. Metab. 82,590-599 (1997). 

Lactotropes, somatotropes, thyrotropes, and gonadotropes Lactotropes, somatotropes, and gonadotropes Dualimmuno- labeling Gonzalez et al. unpublished... 

Chandrashekar V, Zaczek D, Bartke A. The consequences of altered somatotropic system on reproduction. Biol Reprod. 2004 71 17-27. 

Although GHRH has a predominant role in sleep regulation, other members of the somatotropic axis may also modulate sleep. Thus, several lines of evidence indicate that GH may stimulate REM sleep (35), and under chronic conditions, it may also stimulate NREM sleep, particularly the intensity of NREM sleep (36). The latter action might be mediated via IGF-1, which has a modest NREM-sleep-promoting activity (29). Finally, stimulation of somatostatin-2 receptors by somatostatin acutely inhibits NREM sleep (37). This action is attributed to an inhibition of GHRHergic neurons. In addition, somatostatin has been implicated in the promotion of REM sleep (38). 

Van Cauter E, Plat F. Interrelations between sleep and the somatotropic axis. Sleep 1998 21 553-565. 

Obal F, Jr., Krueger JM. The somatotropic axis and sleep. Rev Neurol (Paris) 2001 157 5S12-5S15. 

Sautin, Yu. Yu. and Romanenko, V.D. (1982). Effect of photoperiod and temperature on somatotropic and lactotropic activity of the hypophysis of carp (In Russian). Zhumal Evolutsionnoy Biokhimii i Physiologii 28,471-477. 

Veldhuis JD (1996) Gender differences in secretory activity of the human somatotropic (growth hormone) axis. Eur J Endocrinol 734 287-295. 

GRH, growth hormone-RH = somatorelin stimulates the release of GH (growth hormone = STH, somatotropic hormone). Luellmann, Color Atlas of Pharmacology All rights reserved. Usage subject to terms... 

GH is synthesized by the somatotropic (acidophilic) cells of the adenohypophysis and is stored within intracellular granules. During the daytime hours, the plasma concentration of GH in normal adults remains stable and relatively low (<2ng/mL), with several secretory spikes occurring approximately 3 hours after meals and after exercise. In contrast, during the evening hours, adults and children show a marked rise in GH secretory activity 90 minutes after the onset of sleep GH concentrations reach a peak value during the period of deepest sleep. This pattern of GH secretion... 

N9. Norbiato, G., Faglia, G., and Silvestrini, F., Induced modifications, by the human somatotropic hormone, on urinary elimination of hydroxyproline in subjects affected by dwarfism of pituitary and thyroid origin. Metabolismo 1, 51-61 (1966). 

Wichtel JJ, Craigie AL, Freeman DA, et al. 1996. Effect of selenium and iodine supplementation on growth rate and on thyroid and somatotropic function in dairy calves at pasture. J Dairy Sci 79 1865-1872. 

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