Solvents syndrome

Chronic moderate- to high-level exposure to some organic solvents, such as carbon disulfide, n-hexane and methyl n-butyl ketone, can cause encephalopathies (14), which have been variously described as organic solvent syndrome , painters syndrome , psycho-organic syndrome , and chronic solvent encephalopathy (15). 

Klinken L, Arlien-Soborg P Brain autopsy in organic solvent syndrome. Acta Neurol... 

Inhaling turpentine oil has a range of harmful effects, and causes an occupational toxic solvent syndrome, known as "painter s disease", which may be recognised by a violet-like odour of the urine. 

Avoiding sick building syndrome requires special consideration of building constmction and maintenance material used. Asbestos, organic solvents, paint sprays, dirty filters, moist environment caused by poorly maintained humidifiers, and dirty HVAC machinery have contributed to the deterioration of indoor air quahty. Nonstop quahty maintenance is required at all times. 

Polakowska B, Byczkowska Z. 1991. Cerebellar syndrome after long-term exposure to organic solvents. Case report. Med Pr 42 355-359. 

From 1 January 2000, Dutch law prohibits the use by professional carpet fitters of solvent-based adhesives. The Organic Psycho Syndrome law concerns the adhering of coverings to floors, stairs, walls and ceilings in houses and any other buildings. Key issue in the OPS law is that professional users are no longer allowed to use products containing more than 0.5% solvents. The law also affects painters and parquet installers. 

Base-catalyzed nucleophilic attack at the 5-position is rare although it can be an efficient process under appropriate conditions. For example, in the synthesis of acquired immune deficiency syndrome (AIDS) drug Nelfinavir , a base-catalyzed thiolysis reaction was used in the final step (Scheme 8.110). The solvent,... 

Goodpasture s syndrome has been reported after exposure to toluene and other organic solvents (11,12,13). 

Errebo-Knudsen EO, Olsen F. Organic solvents and prese-nile dementia (the painters syndrome). A critical review of the Danish literature. Sci Total Environ 1986 48(l-2) 45-67. 

Beirne GJ. Goodpasture s syndrome and exposure to solvents. JAMA 1972 222(12) 1555. 

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