Solvents for screening

The assembly of large screening libraries for HTS requires the development of archival and retrieval systems that can handle solid compounds and compound solutions in microtubes or in plates in either the 96 or the 384 format. Barcodes are used to identify each sample vial, tube, or plate. Databases record which samples are available, what type of sample it is, and how much is available. All solid samples are prepared first as stock (master) solutions ( around 5 mg/mL in DMSO) in 2-D bar-coded tubes that are then aliquotted to plates and processed as described earlier. The tubes and plates are usually made of polypropylene for compatibility with DMSO. DMSO is the industry standard solvent for screening libraries because many of the archived compounds are not soluble in water at 5 mg/mL. DMSO, an organic solvent, also has a favorable combination of biological... 

Table 10.1 gives a list of the properties of solvents that may be important in choosing a solvent for screening for effectiveness. 

Chem. Descrip. Propylene glycol monomethyl ether acetate CAS 108-65-6 EINECS/ELINCS 2( 03-9 Uses Retarder, solvent for gravure inks, lacquers, thinners, baking enamels solvent for screen inks, cosmetics, food-contact applies., coating polymers (CAB, NC, epoxy, acrylic copolymers, phenoxy resins), cleaning fluids, automotive paints process solvent for resin mtg., urethanes Features Slow evaporating... 

Uses Solvent for screen inks, coil coatings, paint strippers, hand cleaners, graffiti removers intermediate for detergents, lubricants, emulsifiers, wetting agents, plasticizers replacement for wh. spirit, isoparaffins, glycols, glycol ethers, ketones, aromatic compds. 

Table 9.1 Classification of organic solvents for screening co-crystals.

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See also in sourсe #XX -- [ ]

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