Quickly Screen Solvents for Organic Solids

Frank et aL reported examples of quickly screening solvents for organic solids. In one particular example, solubilities of aspirin in four different solvents (acetone, ethanol, chloroform, and cyclohexane) were used to regress the Hansen solubility parameters for the solute, aspirin. Once the Hansen solubility parameters are identified for aspirin, Frank et al. showed that one could quickly estimate the solubilities of aspirin in any solvent or solvent mixture as long as the Hansen solubility parameters are also available for the solvents. 

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Frank TC, DowneyJR, and Gupta SK. Quickly Screen Solvents for Organic Solids. Chem Eng Progress 1999 95 41-61. 

Recently, Frank et al. (1999) presented a good review of these and other calculation-based methods to quickly screen solvents for use in organic solids crystallization processes. 

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