Solvent-free organic reactions

Novel solvent-free organic reactions using focused microwaves with formation of heterocycles 98S1213. 

H. Kotsuki, T. Shimanouchi, R. Ohshima, and S. Fujiwara, Solvent-free organic reactions on silica gel supports. Facile transformation of epoxides to /i-halohy-drins with lithium halides, Tetrahedron, 54 (1998) 2709-2722. 

Microwave-accelerated Solvent-free Organic Reactions... 

Microwave-accelerated reactions, miscellaneous, 76 580-584 Microwave-accelerated solvent-free organic reactions, 76 551, 555—584 Microwave-assisted synthesis, of... 

Microwave technology—chemical synthesis applications, 16 538-594 microwave-accelerated solvent-free organic reactions, 16 555-584 microwave-assisted organic reactions in the liquid phase, 16 540-555 Microwave technology, 16 509-537. See also Microwave power Microwave technology— chemical synthesis applications... 

Cleophax, J., Liagre, M., Loupy, A. and Petit, A., Application of focused microwaves to the scale-up of solvent-free organic reactions, Org. Process. Res. Dev., 2000, 4,498. 

The elimination of volatile organic solvents in organic syntheses is a most important goal in green chemistry. Solvent-free organic reactions make syntheses simpler, save energy, and prevent solvent wastes, hazards, and toxicity. 

This volume is a compilation of solvent-free organic reactions, covering important papers published during the past two decades. It contains graphical summaries of 537 examples of solvent-free organic reactions and is divided into 14 chapters ... 

When a mixture of acetophenone 59a (1.0 g, 8.3 mmol), NaBH4 (0.94 g, 24.9 mmol), and water (10 ml) was stirred at room temperature for 2 h, rat-60a was produced. To the water suspension medium of rac-60a was added powdered 8a (3.87 g, 8.3 mmol), and the mixture was stirred for 3 h to give a 2 1 inclusion complex of 8a with (-)-60a.25 Inclusion complex formed was filtered and dried. Heating of the complex in vacuo gave (-)-60a of 95% ee (0.42 g, 85%). From the filtrate left after separation of the inclusion crystals, (+)-60a of 77% ee (0.35 g, 70%) was obtained by extraction with ether. By the same procedure, optically active 60a and 60c-g were prepared (Table 5). Solid state and solvent-free organic reactions have been well established25,263 0. Host-guest inclusion complexation in the solid state has also been reported.260... 

Z.2 Microwave-accelerated Solvent-free Organic Reactions 367 8.2.1.5 Cleavage of Carboxylic Esters on a Solid Support... 

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