OATP 2 gene

Table 3.1 Oatp/OATP gene classification as implemented by the human and mouse gene nomenclature committees.

SLCO genes encoding human OATP family members... 

Figure 14.5 Schematic diagram of the magnetic isolation method for rat retinal vascular endothelial cells (RVEC) (A) and the transcript level of organic anion-transporting polypeptides (Oatps) in RVEC (B). A Endothelial cells (RVEC) EC, Nonendothe-lial cells (Non-RVEC) Non-EC. B Not detected N.D. Data taken from Journal of Neurochemistry, 91, Tomi and Hosoya, Application of magnetically isolated rat retinal vascular endothelial cells for the determination of transporter gene expression levels at the inner blood-retinal barrier. 1244-1248, 2004, with permission from Blackwell Publishing.

Oatps/OATPs were newly classified within the OATP (protein)/SLCO (gene) (human) and Oatp (protein)AS7co (gene) (rodents) superfamily according to their phylogenetic relationships and chronology of identification. The methods of classification and the nomenclature were described in detail in a recent review [21],... 

Nishizato Y, Ieiri I, Suzuki H, et al. Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes consequences for pravastatin pharmacokinetics. Clin Pharmacol Ther 2003 73 554—565. 

OATP-C, SLCOIBI, Not applicable The reduced activity of novel allele of OATP-C gene [38-40]... 

Recently, the HUGO Gene Nomenclature Committee adopted a new nomenclature, the SLCO (character O is from the head letter of OATP). It is subdivided into families (>40% amino acid sequence identity), subfamilies (>60% amino acid sequence identity), and individual genes and gene products according to their phylogenetic relationships and chronology of identification [2]. 

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