Solid supports cross-reference

Gas chromatography is often divided into categories based on the type of stationary phase used. Gas-liquid chromatography (GLC) implements a porous, inert solid support that is coated with a viscous, nonvolatile liquid phase. On the other hand, gas-solid chromatography (GSC) uses a solid adsorbent as the stationary phase. Klee offers these general rules-of-thumb for selection of stationary phase materials use solid adsorbents to separate room-temperature gases, liquid stationary phases to separate room-temperature liquid and solid mixtures, polar phases for polar solutes, and nonpolar phases for nonpolar solutes. Table 1 lists common liquid- and solid-stationary phase materials available for use in capillary columns. Barry cross-refers numerous column materials from nine different manufacturers. ... 

One of the most developed methods used in combinatorial chemistry libraries preparation is solid-phase organic synthesis (SPOS) based on the Merrifield method for peptide synthesis [128]. A great number of such libraries have been prepared on a solid support, generally a functionalized polystyrene resin cross-linked with a small amount of divinylbenzene. Recently, it was demonstrated that micro-wave irradiation can be applied to solid-phase immobilized reagents to reduce significantly the reaction time. Those readers who are interested in such processes we would like to refer to more extensive reviews published by Chamberlin et al. [129] and Kappe [130], while in this chapter we are giving most common examples. 

Meldal and coworkers developed polyacrylamides cross-linked with poly(ethylene glycol), referred to as PEGA, as supports for solid-phase synthesis and on-bead enzymatic assays [181-183]. Functionalization of the polymer was performed in a similar fashion as in the case of other polyacrylamides, i.e. either by copolymerization with N-acryloylsarcosine ethyl ester followed by aminolysis with ethylenediamine, or by copolymerization with an amino group containing monomer. The monomers used for a high-capacity (0.4-0.8 mmol/g [182]) and a low-capacity (0.2-0.4 mmol/g [181]) PEGA support are sketched in Figure 2.7. 

The basic fluid-bed unit consists of a refractory-lined vessel, a perforated plate that supports a bed of granular material and distributes air, a section above the fluid bed referred to as freeboard, an air blower to move air through the unit, a cyclone to remove all but the smallest particulates and return them to the fluid bed, an air preheater for thermal economy, an auxiliary heater for start-up, and a system to move and distribute the feed in the bed. Air is distributed across the cross section of the bed by a distributor to fluidize the granular solids. Over a proper range of airflow velocities, usually 0.8-3.0 m/s, the solids become suspended in the air and move freely through the bed. 

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