Solid-state fermentation antibiotics

Mizumoto, S., Hirai, M., and Shoda, M. (2006). Production of lipopeptide antibiotic iturin A using soybean curd residue cultivated with Bacillus subtilis in solid-state fermentation. Appl. Microbiol. Biotechnol. 72, 869-875. 

Yang, S. S. (1996). Antibiotics production of cellulosic wastes with solid state fermentation by... 

The fermentation products of Monascus, especially those produced by solid-state fermentation of rice, have been used as food and health remedies for over 1000 years in China. Monascus rice products (MRPs) are currently being used as health foods in the United States and many Asian countries such as Japan, Taiwan, China, Korea, Thailand, the Philippines, and Indonesia. Many studies have shown that Monascus spp. produce commercially viable metabolites, including food colorants, cholesterol-lowering agents, and antibiotics. The most important bioactive compound isolated from Monascus is monacolin K, which is identical to the potent cholesterol-lowering, antiatherosclerotic drug lovastatin, a 3-hydroxy-3-methylglutaryl... 

Novel quinolone antibiotics, quinolactacins A-C (Schemes 24.22 and 24.23 Table 24.28) were first discovered from the cultured broth of Penicillium sp. EPF-6, which was isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker) [41]. More recently, the two quinolactacin A diastereomers were isolated from solid-state fermentation of Penicillium citrinum 90648 and named... 

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