Solid molecular recognition

Macroheterocycles as components of systems capable of molecular recognition in lamellar solids and thin films 98ACR209. 

Chirality and molecular recognition in monolayers at the air-water interface, 28,45 CIDNP and its applications, 10, 53 Conduction, electrical, in organic solids, 16,159... 

It was quickly recognized that chirality would play an important role in discotic liquid crystals, not only for the possibility of creating cholesteric and ferroelectric liquid crystals but also as a tool for studying the self-assembly of these molecules as a whole, both in solution and in the solid state. However, initial studies revealed that expression of chirality in discotic liquid crystals was not as straightforward as for liquid crystals derived from calamitic molecules. More recently, with the increase in interest in self-assembly and molecular recognition, considerably more attention has been directed to the study of chiral discotics and their assemblies in solution. The objective of this chapter is... 

Protein molecular organization on solid matrices has intensively been explored in various manners. Although most of these researchers have not paid attention on retainment of protein functions, this chapter focuses on artificially designed protein organizates which are capable of molecular recognition and molecular information transduction. 

The interactions between solutes and solvents are noncovalent in nature (barring the occurrence of chemical reactions), and therefore fall into the same category as those that govern molecular recognition processes, the formation and properties of liquids and solids, physical adsorption, etc. Hydrogen bonding, in its many manifestations, is a particularly prominent and important example. 

The exploitation of the reactivity of molecular crystals lies close to the origins of crystal engineering and is at the heart of the pioneering work of Schmidt [47a]. The idea is that of organizing molecules in the solid state using the principles of molecular recognition and self-assembly. Successful results have been obtained with bimolecular reactions, particularly [2+2] photoreactivity and cyclisation [47b,c]. Another important area is that of host-guest chemistry. 

Haley MM, Pak JJ, Brand SC (1999) Top Curr Chem 201 81 HOger S (1999) J Polym Sci A Polym Chem 37 2685 Bunz UHF, Rubin Y, Tobe Y (1999) Chem Soc Rev 28 107 Faust R (1998) Angew Chem Int Ed 37 2825 Moore JS (1997) Acc Chem Res 30 402 Zhao D, Moore JS (2003) Chem Commun 807 Nelson JC,Saven JG,Moore JS,Wolynes PG (1997) Science 277 1793 Shetty AS, Zhang J, Moore JS (1996) J Am Chem Soc 118 1019 Prince RB,Saven JG,Wolynes PG,Moore JS (1999) J Am Chem Soc 121 3114 Hill DJ, Moore JS (2002) Proc Natl Acad Sci USA 99 5053 Cantor CR, Schimmel PR (1980) Biophysical chemistry. Freeman, San Francisco Prince RB (2000) Phenylene ethynylene foldamers cooperative conformational transition, twist sense bias, molecular recognition properties, and solid-state organization. PhD thesis. University of Illinois at Urbana-Champaign... 

In excerpt I5D, Walker begins with a statement of the topic (solvation at hydrophobic and hydrophilic solid-liquid interfaces) and then moves directly to the signihcance of the work. He emphasizes the need for information on interfacial phenomena and points out possible applications of his work for other areas of science (molecular recognitions, electron transfer, and macromolecular self-assembly). He goes on to describe his experimental methods, focusing on three aspects of his approach (in order of difficulty) equilibrium measurements, time-resolved studies, and distance-dependent measurements of solvation strength. 

The all-important finding that carboxylate-appended sapphyrins can self-assem-ble was confirmed in the case of the sapphyrin monocarboxylate 6. ° For both compounds the self-assembly phenomena were shown to take place not only in the solid state, but also in solution and in the gas phase (see Section 3.3). This meant that the carboxylate-binding properties of the sapphyrins could be used as the key molecular recognition basis for engendering the spontaneous self-assembly of appropriately designed supramolecular ensembles. 

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