Sodium sulfanilamide

Trichloropyrazine reacts similarly with concentrated ammonium hydroxide at 80° to give exclusively 3-amino-2 -dichloropyrazine (365b). It has also been claimed (845) that 2,3,5-trichloropyrazine reacts with sodium sulfanilamide in acetamide at 100° or with excess aqueous ammonia at 100° by replacement of the... 

Aminoisoxazoles can be determined photometrically by reaction with sodium 1,2-naph-thoquinone-4-sulfonate and selective extraction of the resulting dye into CCI4 for absorbance measurements. This class of compound can be determined in the presence of sulfonamides, sulfanilamides, hydroxylamines and other select amines (74MI41610). 

Similar selectivity in displacement reactions is shown by 3,6-dichloropyridazine (153) (available by halogenation of the product from maleic anhydride and hydrazine). Thus, reaction of the dihalide with the sodium salt from sulfanilamide (93) affords fiulfachloropyridazine (104). Reaction of this last with sodium methoxide under somewhat more drastic conditions results in displacement of the remaining chlorine to give sulfamethoxypyrida-zine (105). ... 

In another approach to the required functionality, the sodium salt of acetyl sulfanilamide (196) is condensed with butyl... 

C1H03S 7790-94-5) see Actinoquinol Azosemide Bendroflumethiazide Clopamide Diclofenamide Diethylstilbestrol disulfate Dorzolamide Furosemide Glibenclamide Glimepiride Hydroflumethiazide Lomoxicam Mafenide Meticrane Metolazone Saccharin Sildenafil Sodium picosulfate Sulfanilamide Tiotixene Tripamide Xipamide... 

Sodium Acetate Sodium Cyanide Sodium Formate Sulfanilamide Thiourea Toluene... 

N1 -acylsulfanilamides, 23 508 A21-heterocyclic derivatives, 23 508 Ar -heterocyclic-Ar -acylsulfanilamides, 23 508 A21-heterocyclic sulfanilamides, 23 507—508 2V-(2-aminoethyl)-l,3-propylenediamine physical properties, 5 486t 2V-(2-aminoethyl)-piperazine (AEP), 5 485 N2 oxidation, Birkeland-Eyde process of, 27 291-292, 316. See also Dinitrogen entries Nitrogen entries N3 -P5 phosphoramidates, 27 630-631 Na+, detection in blood, 24 54. See also Sodium entries Nabarro-Herring creep, 5 626 Nacol 18, chain length and linearity, 2 10t Nacreous pigments, 7 836-837 19 412 Nacrite, 6 659... 

The basic formula of the sulfonamides and their structural similarity to p-aminobenzoic acid (PABA) are shown in Figure 46-1. Sulfonamides with varying physical, chemical, pharmacologic, and antibacterial properties are produced by attaching substituents to the amido group (-SO2-NH-R) or the amino group (-NH2) of the sulfanilamide nucleus. Sulfonamides tend to be much more soluble at alkaline than at acid pH. Most can be prepared as sodium salts, which are used for intravenous administration. 

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