Glibenclamide Furosemide

C1H03S 7790-94-5) see Actinoquinol Azosemide Bendroflumethiazide Clopamide Diclofenamide Diethylstilbestrol disulfate Dorzolamide Furosemide Glibenclamide Glimepiride Hydroflumethiazide Lomoxicam Mafenide Meticrane Metolazone Saccharin Sildenafil Sodium picosulfate Sulfanilamide Tiotixene Tripamide Xipamide... 

Clinically important, potentially hazardous interactions with amphotericin B, benzodiazepines, doripenem, ertapenem, fludoxacillin, furosemide, glibenclamide, ketoprofen, ketorolac, methotrexate, NSAIDs, pemetrexed, penicillamine, penicillin G, penicillin V, salicylates, sulfamethoxazole, sulfonamides, torasemide, torsemide... 

Noninterfering amiloride, acebutolol, acenocoumarol, acetaminophen, aspirin, allopuri-nol, ambroxol, amoxicillin, atenolol, bendroflumethiazide, benzbromarone, bezafibrate, biperiden, bisacodyl, bromazepam, butizide, captopril, cimetidine, ciprofloxacin, clobu-tinol, clonidine, cotinine, diazepam, diclofenac, digitoxin, digoxin, dihydrocodeine, dihy-droergotamine, diltiazem, doxepin, doxycycline, enalapril, erythromycin, fenoterol, furosemide, glibenclamide, heparin, h3qjoxanthine, ibuprofen, indomethacin, isosorbide... 

The majority of characterized solvates are stoichiometric, with either water or organic solvents present in a Lxed ratio with the drug molecules. Glibenclamide was isolated as two nonsolvated polymorphs, a pentanol solvate, and a toluene solvate (Suleiman and Najib, 1989). Furosemide could form solvates with dimethylformamide or dioxane (Matsuda and Tatsumi, 1989). Haleblian and McCrone (1969) studied the solid forms of steroids, and found different dissolution rates for two monohydrates of Luprednisolone, a monoethanol and hemiacetone solvate of prednisolone and two monoethanolates and a hemichloroform solvate of hydrocortisone. Other solvents that have been reported to form solvates with drugs include methyl ethyl ketone, propanol, hexane, dimethylsulfoxide, acetonitrile, and pyridine. The potential toxicity concerns eliminate most of these from consideration as practical mechanisms of solubility enhancement for human therapeutics. 

Ultrafiltration has been used to determine the protein bound fraction of many drags, such as methadone (Wilkins et al. 1997), phenylacetate and phenylbu-tyrate (Boudoulas et al. 1996), etoposide (Robieux et al. 1997), doxorubicin and vincristine (Mayer and St-Onge 1995), disopyramide (Echize et al. 1995), and ketamine and its active metabolites (Hijazi and Boulieu 2002). Schumacher et al. (2000) have shown the applicability for the determination of erythro-cyte/plasma distribution. The method of UF has been applied in the measurement of free unaltered thyroxin or after displacement by salicylate as well after displacement by heparin in healthy people and in patients with non-thyroidal somatic illness (Faber et al. 1993). The protein binding of tritium labeled, antidiabetic repaglinide and its displacement by warfarin, furosemide, tolbutamide, diazepam, glibenclamide and nicardipine were determined by ultrafiltration (Plumetal. 2000). 

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